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Table 2 Hazard ratios from the Cox proportional hazards model comparisons of the time to onset of convulsions obtained for bupropion metabolites and bupropion HCl in mice

From: Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice

 

Predictors

Bupropion HCl

Erythrohydrobupropion HCl

Threohydrobupropion HCl

Hydroxybupropion HCl*

Treatment

HR = 0.006

(p < 0.0001)

HR = 0.20

(p = 0.0002)

HR = 0.47

(p = 0.0310)

 

Dose

(25, 50, and 75 mg/kg)

HR = 1.10

(p < 0.0001)

HR = 1.09

(p < 0.0001)

HR = 1.11

(p < 0.0001)

  1. *Hydroxybupropion HCl treatment was used as the control treatment for comparison because the number of events (convulsing mice/convulsions) in the bupropion HCl treatment was small and the hydroxybupropion HCl treatment induced convulsions in all 10 mice in the 50 and 75 mg/kg dose groups. HR, hazard ratio for the comparison of the treatment vs hydroxybupropion HCl.
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Annals of General Psychiatry

ISSN: 1744-859X