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Figure 4 | Annals of General Psychiatry

Figure 4

From: Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry

Figure 4

Positron emission tomography (PET) images of cerebral blood flow changes during transient induced sadness in healthy controls (left); pre deep brain stimulation (DBS) in depressed patients (centre); and 3-month post DBS in treatment responsive patients (right). Hyperactivity in Cg25 and hypoactivity in the dorsolateral prefrontal cortex (DLPFC) is evident during low mood and depression. This situation is reversed during remission of symptoms. ACC, anterior cingulate cortex; ins = insular; PF, prefrontal cortex [51, 95].

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Annals of General Psychiatry

ISSN: 1744-859X