Application of Clozapine to aggressive patients
© Tonev et al.; licensee BioMed Central Ltd. 2008
Published: 17 April 2008
Definitions. Aggression types. Therapeutic methods for coping aggression.
Assessment of the drug effect in aggressive patients with different nosological belonging.
Materials and methods
Three groups of patients /aggressive patients with schizophrenia, potentially aggressive patients with schizophrenia and aggressive patients with personal disorder/ age 18-60, without any significant somatic diseases, with diagnosis paranoid schizophrenia and personal disorder, are studied. Clozapine is applied in variable doses. A battery of psychological tests for aggression assessment is used. Personality evaluation was made by IPDE for patients with personality disorders. Diagnostic procedures included ICD-10 criteria.
There is a considerable reduction of aggressive behaviour by fast dosage titration of Clozapine. The side effects affect significantly the patients' compliance
It is observed a good compliance in low Clozapine dosage (under 100 mg.). We consider that the better compliance is also linked with a regular blood count providing therapeutic contacts with patients.
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