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Application of Clozapine to aggressive patients


Definitions. Aggression types. Therapeutic methods for coping aggression.

Assessment of the drug effect in aggressive patients with different nosological belonging.

Materials and methods

Three groups of patients /aggressive patients with schizophrenia, potentially aggressive patients with schizophrenia and aggressive patients with personal disorder/ age 18-60, without any significant somatic diseases, with diagnosis paranoid schizophrenia and personal disorder, are studied. Clozapine is applied in variable doses. A battery of psychological tests for aggression assessment is used. Personality evaluation was made by IPDE for patients with personality disorders. Diagnostic procedures included ICD-10 criteria.


There is a considerable reduction of aggressive behaviour by fast dosage titration of Clozapine. The side effects affect significantly the patients' compliance


It is observed a good compliance in low Clozapine dosage (under 100 mg.). We consider that the better compliance is also linked with a regular blood count providing therapeutic contacts with patients.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tonev, R., Donchev, T. & Nakov, V. Application of Clozapine to aggressive patients. Ann Gen Psychiatry 7 (Suppl 1), S150 (2008).

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