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Ziprasidone-induced hyperprolactinemia: a case report


Among the second-generation antipsychotics, ziprasidone seems to be less frequently associated with hyperprolactinemia. A MEDLINE search (2002-2006) revealed three cases of ziprasidone induced hyperprolactinemia. We describe the case of a patient in whom ziprasidone induced clinically significant hyperprolactinemia.

Materials and methods

Ms. A, a 22-year old woman, had a 1-year history of paranoid schizophrenia with delusions and auditory hallucinations. Four months ago, she was treated with ziprasidone 80mg/day. On day 7, the ziprasidone dose was increased to 160 mg/day, because of insufficient suppression of her psychotic symptoms.


After 5 weeks of ziprasidone treatment, the patient reported significant improvement of psychotic symptoms. However, she complained of galactorrhea, breast tenderness and amenorrhea. Magnetic resonance imaging (MRI) of the head showed no pathology, but her prolactin levels were increased to 47.4 ng/ml. Ziprasidone was discontinued and 3 days after, the patient's prolactin levels were decreased to 3.7 ng/ml and 2 weeks after clinical side effects disappeared.


To our knowledge, this is the fourth case of ziprasidone-induced clinically significant hyperprolactinemia. In this respect, the clinicians' awareness and the monitoring of prolactin level are required.


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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saitis, M., Katsigiannopoulos, K. & Papazisis, G. Ziprasidone-induced hyperprolactinemia: a case report. Ann Gen Psychiatry 7 (Suppl 1), S152 (2008).

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