Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Frontal functioning alterations in chronic hepatitis C virus infected patients

  • Bruno Peixoto1,
  • Laudino Lopez2,
  • Jorge Areias3,
  • Rute Cerqueira4 and
  • Jorge Arias2
Annals of General Psychiatry20087(Suppl 1):S169

https://doi.org/10.1186/1744-859X-7-S1-S169

Published: 17 April 2008

Background

The neuropsychological implications of severe liver dysfunction have been widely discussed in recent neuropsychological literature. However, research has only just begun on the harmful effects of mild liver dysfunction on neurocognitive processes, as well as the direct action of the hepatitis C virus (HCV) on the central nervous system. The purpose of this study was to investigate the possible existence of alterations in the executive functions of HCV patients.

Materials and methods

The executive functions were assessed by the administration of the two tests batteries related to the frontal lobe functioning; the Behavioural Assessment of the Dysexecutive Syndrome and the Wisconsin Card Sorting Test, to a group of HCV patients (n=20) and to a control group (n= 20).

Results

The obtained results suggest the presence of impaired capability to inhibit previous associations and to use feedback in order to correct behaviour in the HCV group. Structured planning, conceptualization, organized search, attention supervision and control in non routine tasks and maintenance of a non automatic response, are other impaired aspects in these patients.

Conclusions

These results were not related to the degree of liver fibrosis, suggesting direct action of the hepatitis C virus on the frontal lobe

Declarations

Acknowledgements

Cespu, crl.

Authors’ Affiliations

(1)
Sciences Department;, Health Sciences Superior Institute – North
(2)
Psychology Department;, viedo University
(3)
Gastroenterology Service;, Saint Antonio General Hospital
(4)
Gastroenterology Service;, Saint Sebastian Hospital

References

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Copyright

© Peixoto et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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