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  • Poster presentation
  • Open Access

Frontal functioning alterations in chronic hepatitis C virus infected patients

  • 1,
  • 2,
  • 3,
  • 4 and
  • 2
Annals of General Psychiatry20087 (Suppl 1) :S169

  • Published:


  • Executive Function
  • Frontal Lobe
  • Liver Fibrosis
  • Liver Dysfunction
  • Automatic Response


The neuropsychological implications of severe liver dysfunction have been widely discussed in recent neuropsychological literature. However, research has only just begun on the harmful effects of mild liver dysfunction on neurocognitive processes, as well as the direct action of the hepatitis C virus (HCV) on the central nervous system. The purpose of this study was to investigate the possible existence of alterations in the executive functions of HCV patients.

Materials and methods

The executive functions were assessed by the administration of the two tests batteries related to the frontal lobe functioning; the Behavioural Assessment of the Dysexecutive Syndrome and the Wisconsin Card Sorting Test, to a group of HCV patients (n=20) and to a control group (n= 20).


The obtained results suggest the presence of impaired capability to inhibit previous associations and to use feedback in order to correct behaviour in the HCV group. Structured planning, conceptualization, organized search, attention supervision and control in non routine tasks and maintenance of a non automatic response, are other impaired aspects in these patients.


These results were not related to the degree of liver fibrosis, suggesting direct action of the hepatitis C virus on the frontal lobe



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Authors’ Affiliations

Sciences Department;, Health Sciences Superior Institute – North, Gandra, Portugal
Psychology Department;, viedo University, Oviedo, Espaρa
Gastroenterology Service;, Saint Antonio General Hospital, Porto, Portugal
Gastroenterology Service;, Saint Sebastian Hospital, Santa Maria da Feira, Portugal


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© Peixoto et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.