Skip to main content
  • Poster presentation
  • Open access
  • Published:

High plasma Amyloid β42 and P-tau in mild cognitive impairment as risk factors of the disease


Patients with mild cognitive impairment (MCI) is reported to develop Alzheimer's disease (AD) at the rate of 12% per year, greatly exceeding the 1% to 2% incidence of normal controls. Several studies have shown an increase in plasma Aβ42 in MCI compared to normal and AD patients. The efficiency of Aβ peptides elimination in earlier stages of AD has proven in animal models. We found no study measuring phospho-tau (p-tau) level in plasma.

Materials and methods

We measured the plasma level of Aβ42 and p-tau181 in 7 patients with MCI, 29 AD and 16 normal controls who had also underwent brain SPECT imaging.


Plasma levels of Aβ42 and p-tau were significantly higher in MCI (57.9±33.3 pg/ml) (44.5± 91.5pg/ml) comparing AD (16.3±15.5pg/ml) (3.4±10.7pg/ml) and normal group (12±7.7pg/ml) (00 pg/ml) (p<0.000) (p<0.010) respectively.

P-tau was not detectable in normal group but p-tau was detectable in (57%) (4/7) of patients with MCI and 4 patients with AD. 3 patients with MCI who had high plasma Aβ42 and detectable p-tau too, had shown bilateral

Posterior temporoparietal hypoperfusion and one showed not-characteristic perfusion defects in SPECT.


Since high plasma Aβ42 and p-tau in our patients with MCI were accompanied by perfusion defect characteristic of AD which is said to be a sign of the progression of MCI to AD, we suggest the evaluation of plasma Aβ42 and p-tau as the risk factors of the disease in patients with MCI.

Author information

Authors and Affiliations


Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Sedaghat, F., Gotzamani-Psarrakou, A., Dedousi, E. et al. High plasma Amyloid β42 and P-tau in mild cognitive impairment as risk factors of the disease. Ann Gen Psychiatry 7 (Suppl 1), S182 (2008).

Download citation

  • Published:

  • DOI: