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Association of the GABRB3 microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene with autism spectrum disorders in Korean trios

  • Hanik Yoo1,
  • Seockhoon Chung2,
  • Jin Pyo Hong1,
  • Boong-Nyun Kim3 and
  • Soo Churl Cho3
Annals of General Psychiatry20087(Suppl 1):S190

https://doi.org/10.1186/1744-859X-7-S1-S190

Published: 17 April 2008

Keywords

Autism Spectrum DisorderAutism Spectrum DisorderHealthy Control SubjectReceptor SubunitReceptor Beta

Background

This study aimed to identify the association between GABA-A receptor subunit β 3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea.

Materials and methods

Fifty-eight Korean children with ASD (47 boys (81.0%), mean age, 5.5 ± 4.1 years old) were enrolled from the outpatient clinic at a general hospital in Seoul, Korea. In addition, 46 family trios, each consisting of an affected child with ASD and that child's biological parent, were recruited. Eighty-six healthy control subjects (71 males (82.6%), mean age, 33.6 ± 9.3 years old) were also recruited through advertisements in local newspapers. TDT was applied to analyze the preferential intergenerational transmission of GABRB3 microsatellite in 46 complete trios.

Results

183 bp long allele in GABRB3 gene were preferentially transmitted in families with ASD (p = 0.025). A population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism.

Conclusions

Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.

Declarations

Acknowledgements

This study was supported by a research fund of the Clinical Research Institute of Seoul National University Hospital (04-2005-067-0).

Authors’ Affiliations

(1)
Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
(2)
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea
(3)
Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea

References

  1. Cook EH, Courchesne RY, Cox NJ, Lord C, Gonen D, Guter SJ: Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers. Am J Hum Genet. 1998, 62: 1077-1083. 10.1086/301832.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Buxbaum JD, Silverman JM, Smith CJ, Greenberg DA, Kilifarski M, Reichert J: Association between a GABRB3 polymorphism and autism. Mol Psychiatry. 2002, 7: 311-316. 10.1038/sj.mp.4001011.View ArticlePubMedGoogle Scholar
  3. Curran S, Roberts S, Thomas S, Veltman M, Browne J, Medda E: An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet. 2005, 137: 25-28.View ArticleGoogle Scholar

Copyright

© Yoo et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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