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Cytokine gene polymorphism in multiple sclerosis in a hellenic population


Multiple sclerosis (MS) is a chronic, complex, autoimmune, demyelinating disease that affects the Central Nervous System. Cytokine gene polymorhism according to the latest studies, may be considered as an important prognostic indicator in a vast number of autoimmune diseases.

Materials and methods

We investigated 13 cytokine gene polymorphisms in 40 M/S patients and 104 healthy control group. From those 40 patients, 20(group I) were presented with relapsing-remitting type of the disease and the other 20 (group II) with secondary progressive type. Cytokine gene polymorhism was determined by using the PCR-SSP method (Invitrogen, Dynal, Wisconsin, USA).


IL 1a - 889C/T genotype was more frequent in group I patients in comparison to group II (80% vs 40%, p<0,001). IL-2-330/+166 TG/TT and TNFa -308/-238 GG/AG genotypes were also statistically more frequent in group I than in group II (40% vs 10%, p<0,0001 and 50% vs 20%, p<0,001). IL1a -889 C/C genotype and IL4Ra +1902 A/A genotype were found more frequently in group II than in group I patients (60% vs 20%, p<0,001 and 80% vs 50%, p<0,0001).


These preliminary results of the present study suggest that gene polymorphism of the above cytokine may play a significant role in M/S patients evaluation and prognosis.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Routsonis, A., Daniilidis, M., Paschalidou, M. et al. Cytokine gene polymorphism in multiple sclerosis in a hellenic population. Ann Gen Psychiatry 7 (Suppl 1), S217 (2008).

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