Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Cytokine gene polymorphism in multiple sclerosis in a hellenic population

  • Alexios Routsonis1,
  • Michael Daniilidis2,
  • Marina Paschalidou1,
  • Georgia Kokaraki3,
  • Stamatia Magiria5,
  • Eleftherios Stamboulis4,
  • Konstantinos Voumvourakis4 and
  • Nikolaos Taskos1
Annals of General Psychiatry20087(Suppl 1):S217

https://doi.org/10.1186/1744-859X-7-S1-S217

Published: 17 April 2008

Background

Multiple sclerosis (MS) is a chronic, complex, autoimmune, demyelinating disease that affects the Central Nervous System. Cytokine gene polymorhism according to the latest studies, may be considered as an important prognostic indicator in a vast number of autoimmune diseases.

Materials and methods

We investigated 13 cytokine gene polymorphisms in 40 M/S patients and 104 healthy control group. From those 40 patients, 20(group I) were presented with relapsing-remitting type of the disease and the other 20 (group II) with secondary progressive type. Cytokine gene polymorhism was determined by using the PCR-SSP method (Invitrogen, Dynal, Wisconsin, USA).

Results

IL 1a - 889C/T genotype was more frequent in group I patients in comparison to group II (80% vs 40%, p<0,001). IL-2-330/+166 TG/TT and TNFa -308/-238 GG/AG genotypes were also statistically more frequent in group I than in group II (40% vs 10%, p<0,0001 and 50% vs 20%, p<0,001). IL1a -889 C/C genotype and IL4Ra +1902 A/A genotype were found more frequently in group II than in group I patients (60% vs 20%, p<0,001 and 80% vs 50%, p<0,0001).

Conclusions

These preliminary results of the present study suggest that gene polymorphism of the above cytokine may play a significant role in M/S patients evaluation and prognosis.

Authors’ Affiliations

(1)
Department of B Neurology, AHEPA University Hospital Aristotle University of Thessaloniki
(2)
Immunogenetics Laboratory, First Department of Internal Medicine, Faculty of Medicine, Aristotle University of Thessaloniki
(3)
Department of Genetics, Developmental & Molecular Biology, Faculty of Sciences, School of Biology, Aristotle University of Thessaloniki
(4)
2nd Neurology Department of Medicine, Faculty of Medicine, Athens University
(5)
3rd Department of Psychiatry, Aristotle University of Thessaloniki

Copyright

© Routsonis et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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