Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Cytokine gene polymorphism in multiple sclerosis in a hellenic population

  • Alexios Routsonis1,
  • Michael Daniilidis2,
  • Marina Paschalidou1,
  • Georgia Kokaraki3,
  • Stamatia Magiria5,
  • Eleftherios Stamboulis4,
  • Konstantinos Voumvourakis4 and
  • Nikolaos Taskos1
Annals of General Psychiatry20087(Suppl 1):S217


Published: 17 April 2008


Multiple sclerosis (MS) is a chronic, complex, autoimmune, demyelinating disease that affects the Central Nervous System. Cytokine gene polymorhism according to the latest studies, may be considered as an important prognostic indicator in a vast number of autoimmune diseases.

Materials and methods

We investigated 13 cytokine gene polymorphisms in 40 M/S patients and 104 healthy control group. From those 40 patients, 20(group I) were presented with relapsing-remitting type of the disease and the other 20 (group II) with secondary progressive type. Cytokine gene polymorhism was determined by using the PCR-SSP method (Invitrogen, Dynal, Wisconsin, USA).


IL 1a - 889C/T genotype was more frequent in group I patients in comparison to group II (80% vs 40%, p<0,001). IL-2-330/+166 TG/TT and TNFa -308/-238 GG/AG genotypes were also statistically more frequent in group I than in group II (40% vs 10%, p<0,0001 and 50% vs 20%, p<0,001). IL1a -889 C/C genotype and IL4Ra +1902 A/A genotype were found more frequently in group II than in group I patients (60% vs 20%, p<0,001 and 80% vs 50%, p<0,0001).


These preliminary results of the present study suggest that gene polymorphism of the above cytokine may play a significant role in M/S patients evaluation and prognosis.

Authors’ Affiliations

Department of B Neurology, AHEPA University Hospital Aristotle University of Thessaloniki
Immunogenetics Laboratory, First Department of Internal Medicine, Faculty of Medicine, Aristotle University of Thessaloniki
Department of Genetics, Developmental & Molecular Biology, Faculty of Sciences, School of Biology, Aristotle University of Thessaloniki
2nd Neurology Department of Medicine, Faculty of Medicine, Athens University
3rd Department of Psychiatry, Aristotle University of Thessaloniki


© Routsonis et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.