Skip to main content


You are viewing the new article page. Let us know what you think. Return to old version

Poster presentation | Open | Published:

Psychosis in a multiple sclerosis patient and antipsychotic treatment


Multiple sclerosis (MS) is a central nervous system demyelinating disease usually diagnosed on the basis of typical neurological symptoms and signs, clinical course, and laboratory and neuroradiological findings. Psychiatric symptoms and disorders frequently co-occur in MS.

Materials and methods

We examined the evidence of correlation between relapses of the comorbid psychosis in a multiple sclerosis (MS) patient and progression of the disease. This case report also deals with the antipsychotic treatment and his necessary modifications.


We present a case of a 35 years old male affected by multiple sclerosis in the last 6 years under treatment with interferons. One year after the diagnosis of the demyelinating disease, the patient developed psychiatric manifestations and he referred to a psychiatric clinic where was formulated the diagnosis of psychosis. There was no family or personal history of psychiatric disease or psychotropic medication/substance use. The patient initially has been treated with risperidone and with an exception of a relapse, because of non-compliance, has been almost stable for about 5 years. At the age of 35 years he has been recovered to our clinic due to a severe exacerbation of the psychosis which persistent symptoms leaded to a change of the antipsychotic treatment. Initially he began on sertindole for one month with poor response. Thus he has changed treatment and the following administration of clozapine had as a result the remission of the symptoms.


The progression of the MS frequently comports exacerbation of the symptomatology of the comorbid psychosis. Clozapine seems to constitute a valid treatment.


  1. 1.

    Claudia Diaz-Olavarrieta, Cummings Jeffrey, Julia Velazquez, de al Cadena Claudia Garcia: Neuropsychiatric manifestations of multiple sclerosis. J Neuropsychiatry Clin Neurosci. 1999, 11: 51-53.

  2. 2.

    Lyoo IK, Seol HY, Byun HS: Unsuspected multiple sclerosis in patients with psychiatric disorders: a magnetic resonance imaging study. J Neuropsychiatry Clin Neurosci. 1996, 8: 54-59.

Download references


The authors wish to appreciate the patient for his kind co-operation.

Author information

Correspondence to Ekaterini Georgopoulou.

Rights and permissions

Reprints and Permissions

About this article


  • Multiple Sclerosis
  • Interferon
  • Clozapine
  • Risperidone
  • Multiple Sclerosis Patient