Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Psychosis in a multiple sclerosis patient and antipsychotic treatment

  • Ekaterini Georgopoulou1,
  • Christina Bornivelli1,
  • Ioannis Choustoulakis1 and
  • Polichronis Alivanis2
Annals of General Psychiatry20087(Suppl 1):S254

https://doi.org/10.1186/1744-859X-7-S1-S254

Published: 17 April 2008

Background

Multiple sclerosis (MS) is a central nervous system demyelinating disease usually diagnosed on the basis of typical neurological symptoms and signs, clinical course, and laboratory and neuroradiological findings. Psychiatric symptoms and disorders frequently co-occur in MS.

Materials and methods

We examined the evidence of correlation between relapses of the comorbid psychosis in a multiple sclerosis (MS) patient and progression of the disease. This case report also deals with the antipsychotic treatment and his necessary modifications.

Results

We present a case of a 35 years old male affected by multiple sclerosis in the last 6 years under treatment with interferons. One year after the diagnosis of the demyelinating disease, the patient developed psychiatric manifestations and he referred to a psychiatric clinic where was formulated the diagnosis of psychosis. There was no family or personal history of psychiatric disease or psychotropic medication/substance use. The patient initially has been treated with risperidone and with an exception of a relapse, because of non-compliance, has been almost stable for about 5 years. At the age of 35 years he has been recovered to our clinic due to a severe exacerbation of the psychosis which persistent symptoms leaded to a change of the antipsychotic treatment. Initially he began on sertindole for one month with poor response. Thus he has changed treatment and the following administration of clozapine had as a result the remission of the symptoms.

Conclusions

The progression of the MS frequently comports exacerbation of the symptomatology of the comorbid psychosis. Clozapine seems to constitute a valid treatment.

Declarations

Acknowledgements

The authors wish to appreciate the patient for his kind co-operation.

Authors’ Affiliations

(1)
Department of Psychiatry, Psychiatric Hospital of Tripoli
(2)
Department of Nephrology, General Hospital of Rhodes

References

  1. Claudia Diaz-Olavarrieta, Cummings Jeffrey, Julia Velazquez, de al Cadena Claudia Garcia: Neuropsychiatric manifestations of multiple sclerosis. J Neuropsychiatry Clin Neurosci. 1999, 11: 51-53.View ArticleGoogle Scholar
  2. Lyoo IK, Seol HY, Byun HS: Unsuspected multiple sclerosis in patients with psychiatric disorders: a magnetic resonance imaging study. J Neuropsychiatry Clin Neurosci. 1996, 8: 54-59.View ArticlePubMedGoogle Scholar

Copyright

© Georgopoulou et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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