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Effects of male sex hormones on morphine dependence

  • 1, 2,
  • 1, 2, 3,
  • 1, 2,
  • 1, 2 and
  • 1
Annals of General Psychiatry20087(Suppl 1):S265

https://doi.org/10.1186/1744-859X-7-S1-S265

Published: 17 April 2008

Keywords

  • Morphine
  • Testosterone
  • Sexual Behavior
  • Locomotor Activity
  • Opioid Receptor

Background

Androgenic steroid (testosterone) has different neurobehavioral effects including sexual behaviors, rewards, learning and locomotor activity. Moreover opioids and opioid receptors are highly expressed in the brain regions which mediate both reward and reproductive behaviors. Thus, we investigated the effect of male sex hormones on morphine dependence.

Materials and methods

Male swiss mice (weighing 25-30 g) were divided into 3 main groups: unoperated, sham-operated and orchidectomized (ORC). Morphine dependence was induced in mice by a repeated injection of increasing doses of morphine for 5 days. Then, dependency was assessed using the behavioral model of naloxan-induced withdrawal (jumping behavior and diarrhea). Also, the effect of male hormone (testosterone) in dependency to morphine was assessed in ORC mice.

Results

Obtained results, indicate that gonadectomized mice had a significant decrease in the number of jumps compared with non-operated groups (p<0.001). However there were no significant changes in the mean weight loss. Pretreatment with physiologic dose of testosterone in ORC mice caused a significant increase in jumping but had no effects on weight loss in compare with the appropriate control group.

Conclusions

The results show that the sensitivity of brain opioid systems, controlling some of the behavioral effects of morphine, is influenced by testosterone. More studies are needed to find the underlying mechanism(s) of this effect.

Declarations

Acknowledgements

We thank Drs S. Ejtemaei-Mehr and V. Hoghooghi and M. Ghasemi for their helpful criticisms on this manuscript.

Authors’ Affiliations

(1)
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
(2)
Interdisciplinary Neuroscience Research Program(INRP), Tehran University of Medical Sciences, Tehran, Iran
(3)
Department of Pharmacology,School of Pharmacy, Shahid-Beheshti University of Medical Sciences, Tehran, Iran

References

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Copyright

© Sadeghi et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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