Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Successful and steady response to a combination of lamotrigine and quetiapine of an extremely refractory bipolar I patient previously published as a case report: a seven years follow-up of the case report

  • Konstantinos Fountoulakis1,
  • Stamatia Magiria1,
  • Melina Siamouli1,
  • Panagiotis Panagiotidis1,
  • Nimatoudis Ioannis1,
  • Apostolos Iacovides1 and
  • George Kaprinis1
Annals of General Psychiatry20087(Suppl 1):S283

https://doi.org/10.1186/1744-859X-7-S1-S283

Published: 17 April 2008

Background

We report the seven-year follow up of a 40-years old female bipolar I patient previously published as an extremely refractory depressed patient who had previously responded only temporarily and only to high doses of clomipramine intra-venous (6 amp daily) plus oral 225 mg venlafaxine, in 2000.

Materials and methods

During the 6 years that followed the patient manifested her first manic episode while for the rest of the time she was continuously depressed and attempted suicide three times. She received ECT without any benefit. She presented to us again after her last attempt. The diagnosis changed to Bipolar I disorder, current episode depressive. She was put on quetiapine 1500 mg, lamotrigine 300 mg and topiramate 50 mg daily. For the next 7 months the patient was normothymic with no residual symptoms.

Results

This was the second true normothymic interval (after the 37 days that followed intra-venous clomipramine) since the onset of her disease at the age of 26.

Authors’ Affiliations

(1)
3rd Department of Psychiatry, Aristotle University of Thessaloniki

Copyright

© Fountoulakis et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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