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  • Open Access

The effect of Salvia leriifolia root extracts on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus

  • 1
Annals of General Psychiatry20087 (Suppl 1) :S295

  • Published:


  • Ischemia
  • Lipid Peroxidation
  • Normal Saline
  • Cerebral Ischemia
  • Ethanolic Extract


The previous pathological data has revealed that Salvia leriifolia root extracts have a neuroprotective activity against cerebral ischemia, thus the effect of the root extracts on lipid peroxidation was evaluated using experimental global ischemic-reperfusion in the rat hippocampus.

Materials and methods

Cerebral ischemia was induced using four-vessel-occlusion (4VO) method for 20 min. The aqueous and ethanolic extracts (0.1, 0.2 and 0.4 g/kg), phenytoin, as positive control, (50 mg/kg) and normal saline (10 ml/kg) were administered intraperitoneally 15 min after the induction of ischemia and the administration was continued every 24 hours for 72 hours after induction of ischemia. The malondialdehyde (MDA) level was measured by the thiobarbituric acid (TBA) test.


The transient global cerebral ischemia induced a significant increase in MDA level (p<0.001) in comparison with sham-operated animals. The MDA levels were recovered significantly upon phenytoin and the extracts therapy in the hippocampus of ischemic rats.


These results suggest that S. leriifolia root extracts may have some protective effects against lipid peroxidation during global cerebral ischemia-reperfusion injury in rat hippocampus.

Authors’ Affiliations

Department of Pharmacology, Azad University, Tehran, Iran


© Mahboubobi; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.