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Evaluation of amnesia induced by intracerebroventricular (i.c.v) administration of lithium in an inhibitory avoidance task in mice
© Sadat Shirazi et al.; licensee BioMed Central Ltd. 2008
Published: 17 April 2008
Lithium is used as a stabilizer in mood disorders such as bipolar depression. Studies show that the drug cause memory deficits in patients treated with the drug.
Materials and methods
In the present study using inhibitory avoidance task (step-down model) time of memory impairment by lithium in male NMRI mice has been investigated.
Immediate post-training administration of different doses of lithium (1, 2 and 4 μgr/mouse) impaired memory retention 24h later. Injection of the same doses of lithium 30 min after training showed impairing effect on memory more effectively. With injection of lithium 45 min after training its impairing effect was decreased and only at the dose of 4 μgr/mouse, memory impairment was observed.
The results show that post-training administration of lithium dose-and time-dependently impaired memory of inhibitory avoidance. It can be concluded that lithium impairs memory retention and its effect at 30 min after training was maximum response.
This article is published under license to BioMed Central Ltd.