Table 2 Case series linking isotretinoin and psychiatric side effects
Reference | Year | No. of patients | Psychiatric adverse effect |
|---|---|---|---|
Meyskens [4] | 1982 | 2 | Psychological changes |
Hazen et al. [5] | 1983 | 6 | Depression |
Bruno et al. [18] | 1984 | 22 | Depressive symptoms |
Bigby and Stern [19] | 1983 | 3 | Depression/violent behaviour |
Scheinman et al. [20] | 1990 | 7 | Depression: suicide attempt (1) |
Duke and Guenther [21] | 1993 | 2 | Depression |
Bravard et al. [22] | 1993 | 3 | Depression: suicide attempts (2) |
Byrne et al. [23] | 1998 | 3 | Depression: suicide attempt (1) |
Barak et al. [24] | 2005 | 5 | Affective psychosis/suicide attempts (3) |