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Table 2 The baseline scale scores in aripiprazole randomised controlled trials (RCTs) of acute mania.

From: Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

Trial

PANSS-total

PANSS-positive

PANSS-negative

PANSS-cognitive

PANSS-hostility

N (efficacy sample)

Aripiprazole

CN138-009

-

-

-

-

-

125

CN138-074

61.8 ± 16.7

-

-

-

-

136

CN138-135

62.0 ± 13.7

-

-

15.2 ± 3.4

10.1 ± 3.4

154

CN138-162

54.8 ± 10.3

16.0 ± 3.9

9.6 ± 2.6

14.7 ± 3.9

9.7 ± 2.6

152

CN138-007

-

-

-

-

-

267 -

CN138008

-

-

-

-

-

171

Pooled mean

59.5

16.0

9.6

14.9

9.9

1,005

Pooled SD

13.7

3.9

2.6

3.6

3.0

 

Placebo

CN138-009

-

-

-

-

-

123

CN138-074

62.5 ± 16.5

-

-

-

-

132

CN138-135

63.9 ± 13.1

-

-

15.3 ± 3.6

10.4 ± 3.6

163

CN138-162

54.4 ± 10.3

16.4 ± 4.9

9.4 ± 2.5

14.9 ± 3.7

9.7 ± 2.5

152

CN138-007

-

-

-

-

-

134 -

CN138008

      

Pooled mean

60.3

16.4

9.4

15.1

10.0

704

Pooled SD

13.4

4.9

2.5

3.6

3.1

 

Comparator

CN138-009

      

CN138-074

      

CN138-135

63.2 ± 12.9

-

-

15.6 ± 3.5

10.5 ± 3.5

155

CN138-162

54.1 ± 10.3

16.1 ± 3.9

9.5 ± 2.5

14.6 ± 3.9

9.4 ± 2.5

161

CN138-007

      

CN138008

-

-

-

-

-

158

Pooled mean

58.6

16.1

9.5

15.1

9.9

474

Pooled SD

11.6

3.9

2.5

3.7

3.0

 
  1. Dash indicates missing data.
  2. aCalculated from Suppes et al. 2008 [21]; data were not used for the calculation of the pooled mean because there is no data on the change.
  3. PANSS = Positive and Negative Syndrome Scale.