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Table 6 Factors significantly associated with SF-36 PCS over 6 months of AD treatment

From: The Factors Influencing Depression Endpoints Research (FINDER) study: final results of Italian patients with depression

Independent variables F, P value Estimate 95% CI
PCS at baseline 172, < 0.0001 0.47 0.40 to 0.54
Age 19, < 0.0001 -0.10 -0.14 to -0.05
Any chronic medical conditions (yes vs no) 7, 0.009 -1.61 -2.80 to -0.41
HADS-A at baseline 7, 0.009 0.24 0.06 to 0.42
SSI-somatic at baseline 5, 0.034 -1.16 -2.23 to -0.09
No. of previous episodes of depression 4, 0.036 -0.47 -0.90 to -0.03
Any psychiatric illnesses in the 24 months before baseline observation 4, 0.044 -1.42 -2.80 to -0.04
Class of AD taken between baseline and 3-month observations (4 df) (reference TCA) 2, 0.045 Combinations (NS)  
   Other drugs 3.82 0.67 to 6.97
   SNRI 3.24 0.66 to 5.82
   SSRI (NS)  
No. of dependants 4, 0.050 0.41 0.001 to 0.822
  1. No. of patients = 371, no. of observations = 716.
  2. AD = antidepressant; df = degrees of freedom; HADS-A = Hospital Anxiety and Depression Scale - anxiety; NS = not significant; PCS = physical component summary; SF-36 = Short Form 36; SSI = Somatic Symptom Inventory; TCA = tricyclic/tetracyclic antidepressants.