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Table 7 Factors significantly associated with EQ-5D HSI over 6 months of AD treatment

From: The Factors Influencing Depression Endpoints Research (FINDER) study: final results of Italian patients with depression

Independent variables F, P value Estimate 95% CI
HSI at baseline 32, < 0.0001 0.208 0.136 to 0.280
Switch within or between AD class (2 df) (reference no switch) 11, < 0.0001 Between -0.071 Within -0.222 -0.136 to -0.006 -0.323 to -0.121
SSI-somatic at baseline 12, < 0.001 -0.062 -0.098 to -0.026
No. of previous episodes of depression 9, 0.002 -0.022 -0.036 to -0.008
Any chronic medical conditions (yes vs no) 8, 0.005 -0.055 -0.094 to -0.017
Overall pain VAS at baseline 8, 0.005 -0.001 -0.002 to -0.0003
No. of dependants 7, 0.010 0.018 0.004 to 0.032
HADS-A at baseline 6, 0.019 0.008 0.001 to 0.013
  1. No. of patients = 328, no. of observations = 650. Switch = change between what was taken between baseline and 3-month observation and what was taken between the 3-month and 6-month observations.
  2. AD = antidepressant; df = degrees of freedom; EQ-5D = European Quality of Life-5 Dimensions; HADS-A, Hospital Anxiety and Depression Scale - anxiety; HSI, health status index; SSI = Somatic Symptom Inventory; VAS = visual analogue scale.