Skip to main content

Therapy of addition for Alzheimer's Disease: combination with galantamine and memantine

Background

The efficacy, safety, and tolerability of nootropic cholinergic agent: GALANTAMINE (with a dual mechanism of action on the cholinergic a system) and moderate affinity NMDA- receptor antagonist: MEMANTINE, were assessed taking into account the profile of patients with neurocognitive disorder: Alzheimer's disease, from the clinical aspects and the different classifications.

Materials and methods

The experience included 380 patients who were enrolled in a prospective, observational, multicenter, and open-label study to receive 16 mg/day of galantamine and 30 mg/day of memantine for 12 months of treatment of addition.

Results

The therapeutic response was measured using the Mini Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Alzheimer's Disease Assessment Scale (ADAS-GOG), Functional Activities Questionnaire (FAQ) the Clinical Global Impression Scale (CGI) and the UKU scale of adverse effects taking into account the efficacy, safety and adverse events of the treatment.

Conclusions

The final results of the study showed that galantamine with addition memantine improves cognition, behavioural symptoms, and the general well-being of patients with cognitive impairment: Alzheimer's disease. The incidence of adverse events was not significant and a very good profile of tolerability and safety was observed.

References

  1. 1.

    Blesa R: Galantamine: therapeutics effects beyond cognition. Dement Geriatr Cogn Disord. 2000, 11 (suppl 1): 28-34. 10.1159/000051229.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Sramek JJ, Veroff AE, et al: The status of ongoing trials for mild cognitive impairment. Expert Opin Inveting Drugs. 2001, 10 (4): 741-752. 10.1517/13543784.10.4.741.

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Julio Zarra.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Zarra, J., Schmidt, L. Therapy of addition for Alzheimer's Disease: combination with galantamine and memantine. Ann Gen Psychiatry 9, S118 (2010). https://doi.org/10.1186/1744-859X-9-S1-S118

Download citation

Keywords

  • Mini Mental State Examination
  • Memantine
  • Assessment Scale
  • Behavioural Symptom
  • Clinical Global Impression