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Synthesis and study the analgesic and anti-inflammatory effects of rigid benzofurane 3, 4 dihydroxy chalcon (DHC) in mice

  • Mahmoud Reza Heidari1,
  • Mohammad Heidari1,
  • Alireza Foroumadi2,
  • Ali Asadipour3 and
  • Hojat Noroozi1
Annals of General Psychiatry20109(Suppl 1):S124

https://doi.org/10.1186/1744-859X-9-S1-S124

Published: 22 April 2010

Keywords

Public HealthAnalgesic EffectActivity RelationshipChronic PhaseStructure Activity

Background

According to bibliography on the structure activity relationship, it seems that the rigid Benzofuran dihydroxy chalcon (DHC) may be more effective on pain and inflammation. In this study the Rigid benzofuran DHC were synthesized and the analgesic and anti-inflammatory effect was evaluated.

Materials and methods

In this study the rigid benzofuran DHC were synthesized and the analgesic and anti- inflammatory effect of different doses, 12.5, 25 and 50 mg/kg, was evaluated by formalin hot plate and caregeenan tests, in group of 7 mice.

Results

The resulta showed that 3,4-DHC with dose of 25mg/kg induced significant antinociception and anti-inflammation compared with control group. In additon the effect of DHC was higher in the chronic phase of formalin test, therefore it seems that DHC has better anti-inflammatory effect rather than analgesic effect. The dose of 25 mg/kg of DHC induces significant analgesia in hot plate test and antiu-inflammatory effect in carageenan test too. The doses of 25 and 50 mg/kg, induced lethargy in mice.

Conclusions

The result showed that with modification of structure of the DHC, this derivative has potential for more studies as a lead compound.

Authors’ Affiliations

(1)
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutics, Neuroscience and Physiology Research Centers, Kerman University of Medical Sciences, Kerman, Iran
(2)
Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutics Research Centers, Tehran University of Medical Sciences, Tehran, Iran
(3)
Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutics Research Centers, Kerman University of Medical Sciences, Kerman, Iran

References

  1. Hsieh HK, Lee TH, Wang JP, et al: synthesis and anti - inflammatory effect of chalcones and related compounds. Pharm Res. 1998, 15 (1): 39-46. 10.1023/A:1011940401754.View ArticlePubMedGoogle Scholar
  2. Sogawa S, Nihro Y, Ueda H, et al: 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. J Med Chem. 1993, 36: 3904-3909. 10.1021/jm00076a019.View ArticlePubMedGoogle Scholar

Copyright

© Heidari et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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