Skip to main content

Inflammation and pain

Inflammatory pain is characterized by an increased response to mechanical or heat stimuli, which are normally only mildly painful (mechanical or thermal hyperalgesia). Inflammatory mediators may elicit pain by activating peripheral nociceptors, by promoting further release of inflammatory mediators and, most significantly, by sensitizing primary afferent neurons to any kind of stimuli. On the other hand, leukocytes may counteract the aforementioned effects of inflammation by releasing opioid peptides in peripheral inflammed tissue.

Author information



Corresponding author

Correspondence to Maria Mironidou-Tzouveleki.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Mironidou-Tzouveleki, M. Inflammation and pain. Ann Gen Psychiatry 9, S2 (2010).

Download citation


  • Public Health
  • Peptide
  • Inflammatory Mediator
  • Afferent Neuron
  • Inflammed Tissue