Meeting abstract | Open | Published:
Evaluating the effect of Cannabis sativa seed extraction on memory
Annals of General Psychiatryvolume 9, Article number: S208 (2010)
Δ9-THC is a psychotropic component of Cannabis sativa plant, studies show this matter can bind Cannabinoid receptor in CA1 area of Hippocamp. Thus the aim of this study is evaluation of the effect of aqua extraction Cannabis sativa seed on spatial memory consolidation in rats.
Materials and methods
Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used.
Experimental groups with 25 mg.kg-1, 50 mg.kg-1, 150 mg.kg -1 were injected in the peritoneal (IP) and after one hour of injection spatial memory was scaled.
The results show that experimental groups (50 mg.kg-1,100 mg.kg-1,150 mg.kg -1 doses), for learning time have significant level deduction in the comparison with control group (p < 0.05).
We demonstrate Cannabis sativa seed in low doses can cause Spatial memory improvement but in high dose has not significant level in comparison with control group.
Ramirez Belen, Blazquez Cristina, del Pulgar Teresa, Guzman Manuel, de Ceballos Maria: Prevention of Alzheimer's disease pathology by Cannabinoid:Neuroprtection mediated by blockade of Microglial activation. j neuroscience. 2005, 25 (8): 1904-1913. 10.1523/JNEUROSCI.4540-04.2005.
Le Foll Bernard, Goldberg Steven: Cannabinoid CB1 receptor antagonist as Promising new Medication for drug Depence. j pharmacology. 2004, 312: 875-883.
Castellano C, Rossi-Arnaud C, Cestari V, Costanzi M: Cannabinoids and memory Animal studies. 2003, bentham Science Publishers, 389-402.
Hill MN, Gorzalka BB: Impairment in Endocannabinoid signaling and depressive illness. jama. 2009, 301 (11): 1165-11676. 10.1001/jama.2009.369.
We thank Azad University for support.