Skip to content

Advertisement

  • Meeting abstract
  • Open Access

Evaluating the effect of Cannabis sativa seed extraction on memory

  • 2 and
  • 1
Annals of General Psychiatry20109 (Suppl 1) :S208

https://doi.org/10.1186/1744-859X-9-S1-S208

  • Published:

Keywords

  • Public Health
  • Aqua Extraction
  • Spatial Memory
  • Seed Extraction
  • Memory Consolidation

Background

Δ9-THC is a psychotropic component of Cannabis sativa plant, studies show this matter can bind Cannabinoid receptor in CA1 area of Hippocamp. Thus the aim of this study is evaluation of the effect of aqua extraction Cannabis sativa seed on spatial memory consolidation in rats.

Materials and methods

Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used.

Experimental groups with 25 mg.kg-1, 50 mg.kg-1, 150 mg.kg -1 were injected in the peritoneal (IP) and after one hour of injection spatial memory was scaled.

Results

The results show that experimental groups (50 mg.kg-1,100 mg.kg-1,150 mg.kg -1 doses), for learning time have significant level deduction in the comparison with control group (p < 0.05).

Conclusions

We demonstrate Cannabis sativa seed in low doses can cause Spatial memory improvement but in high dose has not significant level in comparison with control group.

Declarations

Acknowledgements

We thank Azad University for support.

Authors’ Affiliations

(1)
Department of Biology, Azad University of Mashad, Mashhad, Iran
(2)
Department of Statitics, Azad University of Mashad, Mashhad, Iran

References

  1. Ramirez Belen, Blazquez Cristina, del Pulgar Teresa, Guzman Manuel, de Ceballos Maria: Prevention of Alzheimer's disease pathology by Cannabinoid:Neuroprtection mediated by blockade of Microglial activation. j neuroscience. 2005, 25 (8): 1904-1913. 10.1523/JNEUROSCI.4540-04.2005.View ArticlePubMedGoogle Scholar
  2. Le Foll Bernard, Goldberg Steven: Cannabinoid CB1 receptor antagonist as Promising new Medication for drug Depence. j pharmacology. 2004, 312: 875-883.Google Scholar
  3. Castellano C, Rossi-Arnaud C, Cestari V, Costanzi M: Cannabinoids and memory Animal studies. 2003, bentham Science Publishers, 389-402.Google Scholar
  4. Hill MN, Gorzalka BB: Impairment in Endocannabinoid signaling and depressive illness. jama. 2009, 301 (11): 1165-11676. 10.1001/jama.2009.369.View ArticlePubMedGoogle Scholar

Copyright

© Yazdi and Razavi; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

Advertisement