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  • Meeting abstract
  • Open Access

The pharmacotherapy of depression with EPA

  • 1
Annals of General Psychiatry20109 (Suppl 1) :S23

  • Published:


  • Public Health
  • Marked Decrease
  • Ventricular Volume
  • Epidemiological Evidence
  • Biochemical Evidence

This lecture considers the pharmacotherapy of depression with EPA under the following headings:

  • Epidemiological evidence

  • Biochemical evidence

  • First trial of pure EPA in severe treatment-resistant depression

  • Subsequent randomized double-blind placebo-controlled trials

  • Putative mechanisms.

Results obtained from our own group, including structural neuroimaging and 31-phosphorus neurospectroscopy findings, showing an association of EPA treatment of depression with a marked decrease in cerebral phosphodiesters, a marked increase in cerebral phosphomonoesters and reduced lateral ventricular volume, will also be presented.

Authors’ Affiliations

Imperial College London, UK


© Puri; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.