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Pertinent changes in adult brain neurobiology due to trauma


Contrary to the general feeling of safety and stability in contemporary western societies traumatic events arise by nature unrepentantly due to natural disasters, terrorism or criminal acts. People affected in events alter brain development in early ages and differentiate the structure and function of several areas in the adult brain.


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There are important and complex alterations in neurobiological networks that are responsible of triggering defensive reactions of autonomic, immune and endocrine systems forming different aspects of posttraumatic stress disorder. Brain areas involved are thalamus, amygdala, hippocampus, neocortex, corpus callosum and different neurotransmitter systems are accordingly implicated.


The symptomatology of mental disorder is the aftermath of the individual trying to face extraordinary events that fundamentally alter the vision and interpretation of its existence in an environment where the unexpected is the rule and not the exception. Traumatic events put our secluded way of living in danger and have as a consequence the development of different neurobiological responses on various brain circuits leading to the appearance and establishment of mental disorders.

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Correspondence to Christos Tsopelas.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tsopelas, C. Pertinent changes in adult brain neurobiology due to trauma. Ann Gen Psychiatry 9, S29 (2010).

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  • Mental Disorder
  • Corpus Callosum
  • Traumatic Event
  • Posttraumatic Stress
  • Adult Brain