Skip to content

Advertisement

Open Access

Circadian rhythms: strong evidence on how to approach depression

  • Konstantinos N Fountoulakis1
Annals of General Psychiatry20109(Suppl 1):S48

https://doi.org/10.1186/1744-859X-9-S1-S48

Published: 22 April 2010

Keywords

CortisolMelatoninCircadian RhythmMood DisorderCortisol Secretion

It is widely accepted that mood disorders are related to biological rhythm abnormalities. It has been proved that this happens at least in a significant proportion of patients which profit from chronotherapeutic interventions. Rhythm abnormalities in mood disorders include among others diurnal mood variation, elevated nocturnal body temperature, lower nocturnal TSH, overall increased cortisol secretion, phase advance of cortisol and melatonin secration and sleep architecture abnormalities. The exact relationship of these abnormalities to the etiopathogenesis of depression remains unclear; it is however evident that at least some treatment modalities worsen rhythms, leave residual symptoms and therefore do not lead to full remission, which sould be the ultimate goal of any treatment approach. It seems important for an informed approach and understanding of mood disorders and their treatment to take into consideration the normalization and stabilization of endogenous rhythms.

Authors’ Affiliations

(1)
3rdDepartment of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece

Copyright

© Fountoulakis; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

Advertisement