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Table 1 Demographic and baseline clinical characteristics of patients

From: Clinical and economic outcomes of adjunctive therapy with pregabalin or usual care in generalized anxiety disorder patients with partial response to selective serotonin reuptake inhibitors

Characteristic Pregabalin Usual care p
N= 486 N= 239
Age (years), mean (SD) 47.0 (12.6) 45.2 (13.6) 0.070
Sex (female), n (%) 325 (72.9%) 159 (69.1%) 0.307
Body mass index (kg/m2), mean (SD) 25.6 (4.0) 26.1 (4.7) 0.185
Marital status, n (%)    0.625
  Married or with couple 307 (63.2%) 154 (65.0%)  
  Single 105 (21.6%) 57 (24.1%)  
  Widow/er 25 (5.1%) 9 (3.8%)  
  Divorced/separated 49 (10.1%) 17 (7.2%)  
Educational level, n (%)    0.463
  No education 15 (3.1%) 15 (6.3%)  
  Primary education 183 (37.7%) 85 (35.6%)  
  Secondary education 106 (21.9%) 48 (20.1%)  
  Intermediate educational level 102 (21.0%) 46 (19.3%)  
  Higher education (university) 75 (15.5%) 43 (18.0%)  
  Others 4 (0.8%) 2 (0.8%)  
Work status, n (%)    0.219
  Active 251 (51.8%) 119 (49.8%)  
  Housewife 127 (26.2%) 58 (24.3%)  
  Sick leave 47 (9.7%) 11 (4.6%)  
  Unemployed 32 (6.6%) 18 (7.5%)  
  Retired 19 (3.9%) 20 (8.4%)  
  Does not work (students) 4 (0.8%) 7 (2.9%)  
  Others 5 (1.0%) 6 (2.5%)  
Psychiatric comorbidities, n (%)    
  Major depression 89 (18.3%) 41 (17.2%) 0.780
  Panic disorder 67 (13.8%) 22 (9.2%) 0.100
  Social anxiety 48 (9.9%) 16 (6.7%) 0.200
  Phobias 38 (7.8%) 15 (6.3%) 0.550
  Obsessive-compulsive disorder 18 (3.7%) 9 (3.8%) 0.867
  Others 94 (19.3%) 41 (17.2%) 0.542
Medical comorbidities, n (%)    
  Chronic pain 230 (47.3%) 78 (32.6%) <0.001
  Gastrointestinal disease 97 (20.0%) 53 (22.2%) 0.552
  Cardiovascular disease 48 (9.9%) 24 (10.0%) 0.889
  Metabolic disease 25 (5.1%) 21 (8.8%) 0.084
  Genitourinary disease 26 (5.6%) 8 (3.4%) 0.312
  Others 86 (17.7%) 43 (18.0%) 0.996
SSRI distribution by drug, n (%)    
  Paroxetine 177 (36.4) 57 (23.8) 0.001
  Escitalopram 98 (20.2) 49 (20.5) 0.994
  Sertraline 60 (12.3) 42 (17.6) 0.160
  Mirtazapine 67 (13.8) 31 (13.0) 0.852
  Citalopram 52 (10.7) 21 (8.8) 0.596
  Fluoxetine 39 (8.0) 39 (16.3) 0.007
Benzodiazepine use    
  Users, n (%) 405 (83.3) 211 (88.3) 0.177
  Mean (SD) # drugs 0.98 (0.58) 1.06 (0.56) 0.151
Clinical variables, mean (SD)    
  HAM-A scale score 27.2 (6.6) 25.7 (7.2) 0.015
  MADRS scale score 23.6 (6.9) 21.7 (7.5) 0.001
  CGI-I 4.2 (0.8) 4.0 (0.8) 0.001
  1. SD standard deviation; CI confidence interval; HAM-A Hamilton Anxiety Rating Scale; MADRS Montgomery-Asberg Depression Rating Scale; CGI-I Clinical Global Impression-Improvement scale.