Table 3 Main pharmacological treatments during the study with pregabalin or usual care therapy
Pharmacological treatment | Pregabalin | Usual care | p (percentage between groups) | ||||
|---|---|---|---|---|---|---|---|
N = 486 | N = 239 | ||||||
n (%) | Dose | Duration | n (%) | Dose | Duration | ||
mg/day (SD) | months (SD) | mg/day (SD) | months (SD) | ||||
Benzodiazepines | 326 (67.1) | 162 (67.8) | 0.867 | ||||
Alprazolam | 136 (28.0) | 2.0 (1.3) | 4.7 (2.0) | 50 (20.9) | 2.0 (1.4) | 4.7 (1.9) | |
Diazepam | 58 (11.9) | 10.2 (7.1) | 4.4 (2.0) | 26 (10.9) | 12.9 (6.8) | 5.1 (1.7) | |
Lorazepam | 93 (19.1) | 2.6 (1.6) | 4.7 (1.9) | 52 (21.8) | 1.2 (1.3) | 4.8 (1.8) | |
Clorazepate dipotassium | 39 (8.0) | 23.3 (19.7) | 4.4 (2.0) | 26 (10.9) | 15.9 (9.5) | 4.9 (1.5) | |
Bromazepam | 21 (4.3) | 5.7 (6.4) | 4.8 (1.9) | 10 (4.2) | 4.7 (2.1) | 4.9 (1.5) | |
Clonazepam | 16 (3.3) | 9.0 (19.2) | 4.1 (2.4) | 11 (4.6) | 12.6 (13.0) | 4.5 (2.3) | |
Others | 75 (15.4) | - | - | 50 (20.9) | - | - | |
SSRI | 331 (68.1) | 162 (67.8) | 0.933 | ||||
Paroxetine | 121 (24.9) | 24.5 (8.9) | 5.0 (1.9) | 62 (25.9) | 25.6 (10.8) | 5.3 (1.6) | |
Escitalopram oxalate | 97 (20.0) | 18.2 (6.4) | 5.2 (1.5) | 44 (18.4) | 14.9 (4.7) | 4.5 (1.8) | |
Mirtazapine | 63 (13.0) | 26.1 (9.0) | 4.8 (1.8) | 29 (12.1) | 26.0 (6.3) | 5.0 (1.3) | |
Sertraline | 42 (8.6) | 111.9 (53.8) | 5.6 (1.2) | 20 (8.4) | 103.9 (58.4) | 5.5 (1.3) | |
Citalopram | 29 (6.0) | 24.4 (9.2) | 4.8 (1.6) | 15 (6.3) | 23.9 (8.4) | 5.3 (1.1) | |
Fluoxetine | 17 (3.5) | 27.7 (12.0) | 4.5 (2.3) | 18 (7.5) | 27.0 (9.2) | 4.7 (2.2) | |
Others | 12 (2.5) | - | - | 13 (5.5) | - | - | |
SNRI | 106 (21.8) | 39 (16.3) | 0.093 | ||||
Venlafaxine hydrochloride | 61 (12.6) | 155.4 (53.9) | 5.3 (1.4) | 26 (10.9) | 148.0 (47.3) | 5.6 (1.0) | |
Duloxetine | 48 (9.9) | 68.7 (26.9) | 5.5 (1.7) | 13 (5.4) | 61.8 (21.0) | 4.9 (1.6) | |