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Table 3 Main pharmacological treatments during the study with pregabalin or usual care therapy

From: Clinical and economic outcomes of adjunctive therapy with pregabalin or usual care in generalized anxiety disorder patients with partial response to selective serotonin reuptake inhibitors

Pharmacological treatment Pregabalin Usual care p (percentage between groups)
N= 486 N= 239
n (%) Dose Duration n (%) Dose Duration
mg/day (SD) months (SD) mg/day (SD) months (SD)
Benzodiazepines 326 (67.1)    162 (67.8)    0.867
  Alprazolam 136 (28.0) 2.0 (1.3) 4.7 (2.0) 50 (20.9) 2.0 (1.4) 4.7 (1.9)  
  Diazepam 58 (11.9) 10.2 (7.1) 4.4 (2.0) 26 (10.9) 12.9 (6.8) 5.1 (1.7)  
  Lorazepam 93 (19.1) 2.6 (1.6) 4.7 (1.9) 52 (21.8) 1.2 (1.3) 4.8 (1.8)  
  Clorazepate dipotassium 39 (8.0) 23.3 (19.7) 4.4 (2.0) 26 (10.9) 15.9 (9.5) 4.9 (1.5)  
  Bromazepam 21 (4.3) 5.7 (6.4) 4.8 (1.9) 10 (4.2) 4.7 (2.1) 4.9 (1.5)  
  Clonazepam 16 (3.3) 9.0 (19.2) 4.1 (2.4) 11 (4.6) 12.6 (13.0) 4.5 (2.3)  
  Others 75 (15.4) - - 50 (20.9) - -  
SSRI 331 (68.1)    162 (67.8)    0.933
  Paroxetine 121 (24.9) 24.5 (8.9) 5.0 (1.9) 62 (25.9) 25.6 (10.8) 5.3 (1.6)  
  Escitalopram oxalate 97 (20.0) 18.2 (6.4) 5.2 (1.5) 44 (18.4) 14.9 (4.7) 4.5 (1.8)  
  Mirtazapine 63 (13.0) 26.1 (9.0) 4.8 (1.8) 29 (12.1) 26.0 (6.3) 5.0 (1.3)  
  Sertraline 42 (8.6) 111.9 (53.8) 5.6 (1.2) 20 (8.4) 103.9 (58.4) 5.5 (1.3)  
  Citalopram 29 (6.0) 24.4 (9.2) 4.8 (1.6) 15 (6.3) 23.9 (8.4) 5.3 (1.1)  
  Fluoxetine 17 (3.5) 27.7 (12.0) 4.5 (2.3) 18 (7.5) 27.0 (9.2) 4.7 (2.2)  
  Others 12 (2.5) - - 13 (5.5) - -  
SNRI 106 (21.8)    39 (16.3)    0.093
  Venlafaxine hydrochloride 61 (12.6) 155.4 (53.9) 5.3 (1.4) 26 (10.9) 148.0 (47.3) 5.6 (1.0)  
  Duloxetine 48 (9.9) 68.7 (26.9) 5.5 (1.7) 13 (5.4) 61.8 (21.0) 4.9 (1.6)  
  1. SSRI selective serotonin reuptake inhibitors, SNRI serotonin-norepinephrine reuptake inhibitors.