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Table 3 Relationship between methionine and other factors in patients with schizophrenia and normal controls: multiple regression analysis

From: Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia

  Forced entry model Backward elimination model
β ± SD p value VIF β ± SD p value VIF
Normal control
 Sex −0.33 ± 0.23 0.17 1.90 −0.33 ± 0.15 0.04 1.18
 Age 0.55 ± 0.20 0.01 1.51 0.53 ± 0.15 <0.001 1.09
 Smoking status −0.05 ± 0.21 0.92 1.55    
 Vitamin B12 −0.11 ± 0.28 0.70 2.76    
 Folate −0.08 ± 0.24 0.75 2.06    
 Homocysteine −0.08 ± 0.21 0.71 1.55    
 l-serine 0.40 ± 0.28 0.17 2.79 0.43 ± 0.15 0.008 1.13
 d-serine −0.03 ± 0.29 0.92 3.06    
 Glycine 0.02 ± 0.28 0.94 1.91    
 Genotype131 −0.03 ± 0.19 0.89 1.25    
 Genotype133 0.08 ± 0.25 0.75 2.37    
Patients with schizophrenia
 Sex −0.06 ± 0.28 0.83 2.71    
 Age 0.21 ± 0.37 0.57 4.76    
 Duration of illness −0.02 ± 0.32 0.95 3.32    
 Smoking status 0.12 ± 0.25 0.63 2.19    
 CP equivalent dose −0.01 ± 0.28 0.95 1.53    
 Vitamin B12 0.06 ± 0.22 0.74 1.29    
 Folate −0.11 ± 0.21 0.61 1.64    
 Homocysteine −0.29 ± 0.23 0.23 1.93 −0.35 ± 0.16 0.14 1.18
 l-serine 0.15 ± 0.26 0.55 2.31    
 d-serine −0.13 ± 0.27 0.63 2.58    
 Glycine 0.10 ± 0.26 0.67 2.05    
 Genotype131 0.32 ± 0.24 0.20 2.07 0.35 ± 0.16 0.14 1.36
 Genotype133 0.21 ± 0.28 0.46 2.77 0.27 ± 0.18 0.14 1.18
  1. β  standardised partial regression coefficient, VIF variance inflation factor, CP chlorpromazine, SD standard deviation