| Mirtazapine, n = 27 | Sertraline, n = 32 | Paroxetine, n = 18 |
---|---|---|---|
n (%) | n (%) | n (%) | |
Total number of patients with AEs | 16 (59.3) | 7 (21.9) | 12 (66.7) |
Serious AEs (SAEs) | 0 (0.0) | 2 (6.3) | 0 (0.0) |
Brain hemorrhagea | 0 (0.0) | 1 (3.1) | 0 (0.0) |
Hospitalization due to depression deterioration | 0 (0.0) | 1 (3.1) | 0 (0.0) |
AEs leading to discontinuation except for SAEs | 7 (25.9) | 1 (3.1) | 5 (27.8) |
Sedation including somnolence | 3 (11.1) | 0 (0.0) | 0 (0.0) |
Insomnia | 1 (3.7) | 0 (0.0) | 0 (0.0) |
Abnormal liver function test | 1 (3.7) | 0 (0.0) | 0 (0.0) |
Eruption | 1 (3.7) | 0 (0.0) | 0 (0.0) |
Dysgeusia | 1 (3.7) | 0 (0.0) | 0 (0.0) |
Nausea | 0 (0.0) | 1 (3.1) | 1 (5.6) |
Sexual dysfunction (erection failure) | 0 (0.0) | 0 (0.0) | 1 (5.6) |
Mania | 0 (0.0) | 0 (0.0) | 2 (11.1) |
Panic attack | 0 (0.0) | 0 (0.0) | 1 (5.6) |
Specific symptoms of AEs except for SAEs | |||
 Sedation including somnolence | 9 (33.3) | 0 (0.0) | 3 (16.7) |
 Insomnia | 2 (3.7) | 1 (3.1) | 0 (0.0) |
 Akathisia | 1 (3.7) | 0 (0.0) | 2 (11.1) |
 Irritability | 1 (3.7) | 1 (3.1) | 1 (5.6) |
 Mania | 0 (0.0) | 0 (0.0) | 2 (11.1) |
 Weight increased | 3 (11.1) | 0 (0.0) | 0 (0.0) |
 Increased appetite | 1 (3.7) | 0 (0.0) | 0 (0.0) |
 Headache | 0 (0.0) | 0 (0.0) | 2 (11.1) |
 Dizziness | 0 (0.0) | 0 (0.0) | 1 (5.6) |
 Nausea | 1 (3.7) | 5 (15.6) | 4 (22.2) |
 Fatigue | 3 (11.1) | 0 (0.0) | 2 (11.1) |
 Eruption | 1 (3.7) | 0 (0.0) | 0 (0.0) |
 Abnormal liver function test | 1 (3.7) | 0 (0.0) | 0 (0.0) |
 Dysgeusia | 1 (3.7) | 0 (0.0) | 0 (0.0) |
 Sexual dysfunction (erection failure) | 0 (0.0) | 0 (0.0) | 1 (5.6) |
 Hyperhidrosis | 0 (0.0) | 0 (0.0) | 2 (11.1) |
 Constipation | 0 (0.0) | 0 (0.0) | 1 (5.6) |