How obsessive–compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

Table 2 The results of enrichment analysis for pathways, molecular functions, cellular components and brain regions involved in the pathogenesis of both OCD and BD

	Pathway full name	KEGG ID	FDR	Betweenness centrality
1	Dopaminergic synapse	hsa04728	3.86E−08	0.13604918
2	cAMP signaling pathway	hsa04024	1.19E−06	0.12989786
3	Serotonergic synapse	hsa04726	0.000112	0.0838125
4	Calcium signaling pathway	hsa04020	0.000979	0.07812904
5	Glutamatergic synapse	hsa04724	0.001158	0.04450784
6	GABAergic synapse	hsa04727	0.005543	0.03118593
7	Retrograde endocannabinoid signaling	hsa04723	0.00753	0.04801305

	Molecular functions	Gene ontology (GO) ID	FDR	Betweenness centrality
1	Dopamine binding	GO:0035240	3.59E−10	0.011851
2	Dopamine neurotransmitter receptor activity, coupled via Gs	GO:0001588	9.72E−09	0.0047987
3	Extracellular-glutamate-gated ion channel activity	GO:0005234	2.06E−06	0
4	G-protein-coupled amine receptor activity	GO:0008227	0.000142	0.00705387
5	Amino acid binding	GO:0016597	0.000211	0.02687112
6	Kainate-selective glutamate receptor activity	GO:0015277	0.001517	0
7	Monoamine transmembrane transporter activity	GO:0008504	0.004829	0.00237254
8	Serotonin binding	GO:0051378	0.004829	5.53E−04
9	Ammonium transmembrane transporter activity	GO:0008519	0.028746	0.00237254
10	Serotonin receptor activity	GO:0099589	0.028746	5.53E−04

	Cellular components	Gene ontology (GO) ID	FDR	Betweenness centrality
1	Dendrite	GO:0030425	0.000151	0.07980464
2	Axon part	GO:0033267	0.000215	0.03089599
3	Postsynaptic density	GO:0014069	0.000243	0.05051219
4	Ionotropic glutamate receptor complex	GO:0008328	0.001148	0.0055914
5	Membrane raft	GO:0045121	0.001158	0.05504978
6	Cation channel complex	GO:0034703	0.003335	0.02751275
7	Perikaryon	GO:0043204	0.01023	0.00847745
8	Synaptic vesicle	GO:0008021	0.013692	0.01103456

ISSN: 1744-859X