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Table 2 The results of enrichment analysis for pathways, molecular functions, cellular components and brain regions involved in the pathogenesis of both OCD and BD

From: How obsessive–compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

  Pathway full name KEGG ID FDR Betweenness centrality
1 Dopaminergic synapse hsa04728 3.86E−08 0.13604918
2 cAMP signaling pathway hsa04024 1.19E−06 0.12989786
3 Serotonergic synapse hsa04726 0.000112 0.0838125
4 Calcium signaling pathway hsa04020 0.000979 0.07812904
5 Glutamatergic synapse hsa04724 0.001158 0.04450784
6 GABAergic synapse hsa04727 0.005543 0.03118593
7 Retrograde endocannabinoid signaling hsa04723 0.00753 0.04801305
  Molecular functions Gene ontology (GO) ID FDR Betweenness centrality
1 Dopamine binding GO:0035240 3.59E−10 0.011851
2 Dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.72E−09 0.0047987
3 Extracellular-glutamate-gated ion channel activity GO:0005234 2.06E−06 0
4 G-protein-coupled amine receptor activity GO:0008227 0.000142 0.00705387
5 Amino acid binding GO:0016597 0.000211 0.02687112
6 Kainate-selective glutamate receptor activity GO:0015277 0.001517 0
7 Monoamine transmembrane transporter activity GO:0008504 0.004829 0.00237254
8 Serotonin binding GO:0051378 0.004829 5.53E−04
9 Ammonium transmembrane transporter activity GO:0008519 0.028746 0.00237254
10 Serotonin receptor activity GO:0099589 0.028746 5.53E−04
  Cellular components Gene ontology (GO) ID FDR Betweenness centrality
1 Dendrite GO:0030425 0.000151 0.07980464
2 Axon part GO:0033267 0.000215 0.03089599
3 Postsynaptic density GO:0014069 0.000243 0.05051219
4 Ionotropic glutamate receptor complex GO:0008328 0.001148 0.0055914
5 Membrane raft GO:0045121 0.001158 0.05504978
6 Cation channel complex GO:0034703 0.003335 0.02751275
7 Perikaryon GO:0043204 0.01023 0.00847745
8 Synaptic vesicle GO:0008021 0.013692 0.01103456
  Brain regions   FDR Betweenness centrality
1 Cortex   0.008 0.22937063
2 Striatum   0.008 0.1299988
3 Hippocampus   0.008 0.07421981