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Table 2 Sensitivity analysis of the causal association between leisure sedentary behaviors, physical activity and the risk of depression

From: Causal links between sedentary behavior, physical activity, and psychiatric disorders: a Mendelian randomization study

Exposure

Outcome

Cochran Q test

MR‑Egger

MR‑PRESSO

P value

Q value

p

Intercept

p

Television watching

depression

161.853

5.53 × 10− 8

0.0004

0.672

< 0.001

Computer use

depression

27.439

0.168

-0.0007

0.82

0.026

Driving

depression

-

-

-

-

-

MVPA

depression

14.633

0.331

0.004

0.105

0.332

Accelerometer assessed PA

depression

6.645

0.35

0.0013

0.623

0.392

Accelerometer fraction of accelerations > 425 milligravities

depression

3.725

0.713

0.007

0.458

0.732

Television watching

schizophrenia

154.939

6.50 × 10− 10

154.540

4.56 × 10− 10

< 0.001

Computer use

schizophrenia

34.156

0.002

32.672

0.002

0.003

Driving

schizophrenia

6.351

0.012

-

-

-

MVPA

schizophrenia

39.551

8.53 × 10− 5

38.648

6.08 × 10− 5

< 0.001

Accelerometer assessed PA

schizophrenia

9.238

0.099

8.827

0.066

0.137

Accelerometer fraction of accelerations > 425 milligravities

schizophrenia

11.440

0.076

7.256

0.202

0.091

Television watching

bipolar disorder

101.567

6.80 × 10− 5

94.474

2.89 × 10− 4

< 0.001

Computer use

bipolar disorder

16.918

0.261

14.383

0.347

0.273

Driving

bipolar disorder

14.394

0.002

13.522

0.001

-

MVPA

bipolar disorder

15.630

0.270

14.748

0.255

0.353

Accelerometer assessed PA

bipolar disorder

2.286

0.319

0.103

0.749

0.368

Accelerometer fraction of accelerations > 425 milligravities

bipolar disorder

0.088

0.957

0.038

0.845

0.755

  1. MVPA: self-reported moderate to vigorous physical activity. PA: physical activity. - Driving has only one or two SNP