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Effects of neonatal hypoxia on mice behavior and oxidative stress parameters


Approximately 2,9-9,0 of 1000 infants experience some degree of perinatal ischemic-anoxic or prolonged anoxic insult [1].

Materials and methods

Seven days old male Swiss mice were distributed on three groups: hypoxia (H), maternal separation (MS) and no handling (NH). H group underwent to 10% oxygen during 6 hours/day for 6 days and MS group was maintained in normoxia, but separated from their dams such as H group. When mice completed 3 months old, they were tested on locomotor activity boxes or in plus-maze. The parameters measured were erythrocyte catalase, superoxide dismutase and glutathione peroxidase (GPx) and cerebral catalase. Data were analyzed by one-way ANOVA test and Bonferroni post-hoc test, when appropriated.


On the activity boxes, during the 5 first minutes, it was observed a significant decrease of vertical movements on H group, when compared to other groups. However, after 30 minutes, the groups didn't differ. Besides, H mice demonstrated a diverse emotionality on plus-maze, once the quantity of fecal boli and urine was significant different from group NH. Considering oxidative stress, only GPx values were increased on H group compared to MS group.


Neonatal hypoxia is capable of generating long-term alterations on mice behavior and on production and/or activation of some antioxidant enzymes.


  1. Tuor UI, Del Bigio MR, Chumas PD: Brain damage due to cerebral hypoxia/ischemia in the neonate: pathology and pharmacological modification. Cerebrovasc Brain Metab Rev. 1996, 8 (2): 159-193.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brandγo, L.d.C., Abe, K.C., Tufik, S. et al. Effects of neonatal hypoxia on mice behavior and oxidative stress parameters. Ann Gen Psychiatry 7 (Suppl 1), S126 (2008).

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