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Fractal analysis of dendritic arborization patterns of pyramidal neurons in human basolateral amygdala

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2 and
  • 2
Annals of General Psychiatry20087 (Suppl 1) :S141

https://doi.org/10.1186/1744-859X-7-S1-S141

  • Published:

Keywords

  • Public Health
  • Fractal Dimension
  • Pyramidal Neuron
  • Public Domain
  • Fractal Analysis

Background

It is well known that there is important role of amygdala in emotional-cognitive processes, i.e. in emotional and associative learning, fear acquisition and emotional memory [1]. We investigated dendritic branching patterns of pyramidal neurons which are believed to be excitatory. According to our earlier findings pyramidal neurons in human basolateral amygdala have two subtypes - pyramidal slender and pyramidal squat neurons [2]. Fractal analysis, which comes from Mandelbrot's fractal geometry [3], is used as a tool for differentiation of the complexity of neuronal dendritic branching patterns. The measure of dendritic branching represents the fractal dimension of the neuron. In performing this study, we have applied the fractal analysis to the images of neurons, in order to investigate its capability to distinguish between subtypes.

Materials and methods

The images of 14 Golgi-impregnated neurons were classified into two categories based on their somata and dendritic patterns - pyramidal slender and pyramidal squat subtypes. All images were analyzed with the box-counting method using public domain Image J software [4].

Results

Statistical analysis of the obtained data indicated that there was a significant difference (p<0.05) between the calculated means of fractal dimensions between dendritic arbors of two subtypes - slender and squat pyramidal neurons.

Conclusions

This preliminary study of neuronal structure performed on pyramidal neurons of human basolateral amygdala suggests the utility both of fractal analysis and fractal dimension as a useful parameter of the complexity of dendritic structure and indicates their functional complexity.

Authors’ Affiliations

(1)
Institute of Anatomy, School of Medicine, University of Kragujevac, Serbia
(2)
Institute of Biophysics, School of Medicine, University of Belgrade, Serbia

References

  1. McGaugh JL: The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci. 2004, 27: 1-28. 10.1146/annurev.neuro.27.070203.144157.View ArticlePubMedGoogle Scholar
  2. Tosevski J, Malikovic A, Mojsilovic-Petrovic J: Types of neurons and some dendritic patterns of basolateral amygdala in humans - a Golgi study. Ann Anat. 2002, 184: 93-103.View ArticlePubMedGoogle Scholar
  3. Mandelbrot BB: The Fractal Geometry of Nature. 2004, New York: W.N. Freemen and Co, 20th edGoogle Scholar
  4. Milosevic NT, Ristanovic D, Stankovic JB: Fractal analysis of the laminar organization of spinal cord neurons. J. Neurosci. Meth. 2005, 146: 198-204. 10.1016/j.jneumeth.2005.02.009.View ArticleGoogle Scholar

Copyright

© Tosevski et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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