Skip to main content
  • Poster presentation
  • Open access
  • Published:

European mania in bipolar longitudinal evaluation of medication study (EMBLEM): clinical outcomes during the acute phase for the greek population


Bipolar disorder is a life-long psychiatric illness found in 2-5% of the population [1]. The aim of the present study was to describe the 12-week (acute phase) clinical outcomes of Greek standard practice in the pharmacological treatment of acute mania.

Materials and methods

EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year prospective observational study on the outcomes of pharmacological treatment for acute mania. All treatments were at the discretion of the treating psychiatrist. The clinical status of the Greek patients was studied during the first 12 weeks of treatment in the acute phase of the illness, with the use of CGI-BP, YMRS and HAM-D-5.


A total of 3684 patients were enrolled in 14 European countries, between December 2002 and June 2004. The Greek subpopulation consisted of 645 eligible individuals (18%). Greek patients experienced clinical improvement as shown by the decrease in mean CGI-BP overall and mania subscales, YMRS and 5 item HAM-D over 12 weeks of the acute phase. 72% of the Greek patients had improved (defined as the first decrease of a minimum of 2 points in CGI-BP overall at any time during acute phase) and 31% had recovered (defined as a score of 2 or less on CGI-BP overall in the last visit and the visit prior to last). Compliance also improved as the percentage of patients who almost always complied with medication increased from 44% at baseline to 82% at week 12. The majority of patients received atypical antipsychotics either as monotherapy or as combination therapy for the duration of treatment.


This large observational study showed that most patients experienced clinical improvement after 12 weeks of treatment and that atypical antipsychotics were the most commonly taken as combination therapy for acute mania.


  1. Huxley N., Baldessarini R.: Disability and its treatment in bipolar disorder patients. Bipolar Disorders. 2007, 9: 183-196. 10.1111/j.1399-5618.2007.00430.x.

    Article  PubMed  Google Scholar 

Download references


The Hellenic EMBLEM study team: Alexopoulos S, Anagnostara C, Arapidis K, Arvaniti C, Aspradakis E, Bakaras P, Balla A, Baslis D, Chamogeorgakis T, Charalampous A, Chatzakis A, Chatziioannou G, Chatzopoulou P, Christodoulaki M, Daffas A, Deres S, Dimopoulos G, Diakogiannis I, Evangelinos T, Fortos A, Gatos K, Georgila P, Georgopoulou K, Giamoukis S, Giannopoulou K, Iliakis P, Kakkavas P, Kalogeropoulou K, Kanavakis M, Karagiannidis C, Karadedos A, Karvelas A, Kladouchos V, Kolostoumbis D, Konstantinou A, Kontis K, Koufidis V, Lazanakis M, Lennas D, Leotsakou C, Maggouta A, Mallis D, Markadakis C, Mavridakis A, Nikolakakis A, Panagopoulos F, Pappas E, Pastakas S, Potamitis D, Roubos V, Spyropoulou A, Syrmos I, Terzopoulos I, Theodoropoulou P, Valavanis P, Vartzopoulos D, Vasilakos G, Verveniotis S.

Author information

Authors and Affiliations


Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Psarra, V., Drossinos, V., Mantellou, M. et al. European mania in bipolar longitudinal evaluation of medication study (EMBLEM): clinical outcomes during the acute phase for the greek population. Ann Gen Psychiatry 7 (Suppl 1), S180 (2008).

Download citation

  • Published:

  • DOI: