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  • Poster presentation
  • Open Access

Treatment of depersonalization disorder with fluoxetine: a case report

  • 1,
  • 1 and
  • 1
Annals of General Psychiatry20087 (Suppl 1) :S208

  • Published:


  • Public Health
  • Fluoxetine
  • Pharmacological Treatment
  • Successful Treatment
  • Single Case


One small prospective series and two single case reports had described successful treatment of primary depersonalization disorder in a number of patients treated with fluoxetine [13]. But then, one recent randomized, double masked, placebo-controlled trial failed to show efficacy [4]. We present the case of depersonalization disorder that responded favorably to fluoxetine treatment.

Materials and methods

A 23-year old single man had a 1-year history of primary depersonalization disorder. He described feeling “detached from my body, as if I was observing myself from the outside, cut off from emotions and feelings, feeling as if I had completely lost my self and feeling like I was in a dream”. He felt far removed from everything. The patient was treated with fluoxetine 10 mg/day, which was slowly raised to 40 mg/day.


Eight weeks after beginning fluoxetine, the patient had a remarkable improvement. Following complete resolution of the depersonalization symptoms, the patient began to socialize, entertain and work. This is continued for 12 months of follow up.


Fluoxetine may be a promising pharmacological treatment for primary depersonalization disorder.

Authors’ Affiliations

Community Mental Health Center of N/W District, Thessaloniki, Greece


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© Saitis et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.