Skip to content

Advertisement

  • Oral presentation
  • Open Access

Endophenotypes of depression and anxiety

  • 1
Annals of General Psychiatry20087(Suppl 1):S56

https://doi.org/10.1186/1744-859X-7-S1-S56

Published: 17 April 2008

Keywords

  • Public Health
  • Treatment Strategy
  • Brain Imaging
  • Practical Implication
  • Susceptibility Gene

Progress in neurobiology (neurotransmitters, second messengers, early genes, trophic factors, ion channels, genetics, brain imaging) has changed the perspective on psychiatric illness in the last decades, particularly in the field of depression [1] and anxiety [2]. Difficulties in the discovery of susceptibility genes have been attributed to the etiological heterogeneity of the clinical phenotype of the disease [3]. Endophenotypes [14], e.g. neurobiological correlates of depression and anxiety which are genetically determined and mostly stable over time might be better targets for future research and/or treatment strategies. Practical implications of the neurobiology of depression and anxiety are discussed.

Authors’ Affiliations

(1)
Medical University of Vienna, Austria

References

  1. Hasler G, Drevets WC, Manji HK, Charney DS: Discovering endophenotypes for major depression. Neuropsychopharmacology. 2004, 29 (10): 1765-81. 10.1038/sj.npp.1300506.View ArticleGoogle Scholar
  2. Klein DF: Panic and phobic anxiety: phenotypes, endophenotypes, and genotypes. Am J Psychiatry. 1998, 155 (9): 1147-9.View ArticleGoogle Scholar
  3. J Flint, MR Munafo: The endophenotype concept in psychiatric genetics. Psychol Med. 2007, 37 (2): 163-80. 10.1017/S0033291706008750.View ArticleGoogle Scholar
  4. Gottesman II, Gould TD: The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003, 160 (4): 636-45. 10.1176/appi.ajp.160.4.636.View ArticleGoogle Scholar

Copyright

© Erfurth; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Advertisement