Oral presentation | Open | Published:
Endophenotypes of depression and anxiety
Annals of General Psychiatryvolume 7, Article number: S56 (2008)
Progress in neurobiology (neurotransmitters, second messengers, early genes, trophic factors, ion channels, genetics, brain imaging) has changed the perspective on psychiatric illness in the last decades, particularly in the field of depression  and anxiety . Difficulties in the discovery of susceptibility genes have been attributed to the etiological heterogeneity of the clinical phenotype of the disease . Endophenotypes [1–4], e.g. neurobiological correlates of depression and anxiety which are genetically determined and mostly stable over time might be better targets for future research and/or treatment strategies. Practical implications of the neurobiology of depression and anxiety are discussed.
Hasler G, Drevets WC, Manji HK, Charney DS: Discovering endophenotypes for major depression. Neuropsychopharmacology. 2004, 29 (10): 1765-81. 10.1038/sj.npp.1300506.
Klein DF: Panic and phobic anxiety: phenotypes, endophenotypes, and genotypes. Am J Psychiatry. 1998, 155 (9): 1147-9.
J Flint, MR Munafo: The endophenotype concept in psychiatric genetics. Psychol Med. 2007, 37 (2): 163-80. 10.1017/S0033291706008750.
Gottesman II, Gould TD: The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003, 160 (4): 636-45. 10.1176/appi.ajp.160.4.636.