- Oral presentation
- Open Access
The real impact of affective temperaments: new perspectives from Argentina
- Gustavo Hιctor Vázquez1
© Vázquez; licensee BioMed Central Ltd. 2008
- Published: 17 April 2008
- Family History
- Normal Control
- Bipolar Disorder
- Direct Impact
- Degree Relative
We have examined the prevalence of affective temperaments between clinically unaffected relatives of bipolar patients and investigated the impact of these “subaffective” forms on their quality of life (QoL) in seven sites across Argentina.
We administered the scales TEMPS-A Buenos Aires  and Quality of Life Index-Spanish version, to a sample of non-ill first degree relatives of bipolar disorder patients (“cases”) and controls without family history of affective illness.
Mean scores on all TEMPS-A subscales were significantly higher in cases, except for hyperthymia. The prevalence of affective temperaments, according to Argentinean cut-off points , was also higher, with statistical signification for cyclothymic and anxious temperaments. Regarding QoL, we have found an affectation of QoL domains for all temperaments, except hyperthymia. Both findings support the concept of a spectrum of subthreshold affective traits or temperaments in bipolar pedigrees .
Our study confirms that healthy relatives of bipolar probands exhibit a higher degree of temperamental dysregulation than normal controls and demonstrates that affective temperaments can serve as an endophenotype for bipolar disorder  as judged by the fact that “clinically well” relatives show these traits at a statistically significantly higher than appropiately chosen controls.
In this study we go beyond these considerations to test the hyphotesis that the “well relatives” of bipolar probands not only exhibit such traits, but could also show some impairment as a result of a temperamental foundation. Our results support the idea that predominant temperaments have a direct impact on their quality of life (QoL).
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This article is published under license to BioMed Central Ltd.