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Increased plasma levels of 8-Iso-PGF2α in an elderly Greek population with cognitive impairment
Annals of General Psychiatry volume 7, Article number: S97 (2008)
Materials and methods
37 subjects over 60 years of age with dementia and 33 matched controls were randomly selected from a population in the community after screening with the MMSE and application of the diagnostic criteria of the DSM-IV. Plasma concentrations of 8-iso-PGF2α were measured in both groups.
Demented individuals had significantly higher mean (±SD) 8-iso-PGF2α levels compared to healthy controls (237.44 ± 187.44 pg/ml vs 97.64 ± 42.72 pg/ml, respectively, p< 0.05).
This study indicates an association between increased levels of plasma 8-iso-PGF2α and cognitive impairment in the elderly and indicates the necessity for further investigation of oxidative stress and lipid peroxidation in dementia, rendering isoprostanes as plausible biochemical markers of the disease in peripheral blood.
Greco A, Minghetti L, Levi G: Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochem Res. 2000, 25: 1357-1364. 10.1023/A:1007608615682.
Montine T, Quinn J, Montine K, Kaye J, Breitner J: Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer\'s disease. J Alzheimer's Dis. 2005, 8: 359-367.
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Dimopoulos, N., Psarra, V., Mitsonis, C. et al. Increased plasma levels of 8-Iso-PGF2α in an elderly Greek population with cognitive impairment. Ann Gen Psychiatry 7, S97 (2008). https://doi.org/10.1186/1744-859X-7-S1-S97
- Public Health
- Oxidative Stress
- Plasma Concentration