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  • Open Access

Increased plasma levels of 8-Iso-PGF2α in an elderly Greek population with cognitive impairment

  • 1,
  • 2,
  • 2,
  • 1 and
  • 1
Annals of General Psychiatry20087 (Suppl 1) :S97

https://doi.org/10.1186/1744-859X-7-S1-S97

  • Published:

Keywords

  • Public Health
  • Lipid
  • Oxidative Stress
  • Dementia
  • Plasma Concentration

Background

Oxidative damage has been suggested to play a role in dementia [1, 2]. The purpose of the study was to investigate possible implications of lipid peroxidation in cognitive impairment by determining the levels of plasma 8-iso-PGF2α in elderly individuals with dementia.

Materials and methods

37 subjects over 60 years of age with dementia and 33 matched controls were randomly selected from a population in the community after screening with the MMSE and application of the diagnostic criteria of the DSM-IV. Plasma concentrations of 8-iso-PGF2α were measured in both groups.

Results

Demented individuals had significantly higher mean (±SD) 8-iso-PGF2α levels compared to healthy controls (237.44 ± 187.44 pg/ml vs 97.64 ± 42.72 pg/ml, respectively, p< 0.05).

Conclusions

This study indicates an association between increased levels of plasma 8-iso-PGF2α and cognitive impairment in the elderly and indicates the necessity for further investigation of oxidative stress and lipid peroxidation in dementia, rendering isoprostanes as plausible biochemical markers of the disease in peripheral blood.

Authors’ Affiliations

(1)
Laboratory of Biological Chemistry, Medical School, University of Athens, Greece
(2)
Psychiatric Hospital of Attiki, Daphni, Greece

References

  1. Greco A, Minghetti L, Levi G: Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochem Res. 2000, 25: 1357-1364. 10.1023/A:1007608615682.View ArticlePubMedGoogle Scholar
  2. Montine T, Quinn J, Montine K, Kaye J, Breitner J: Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer\'s disease. J Alzheimer's Dis. 2005, 8: 359-367.Google Scholar

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