- Meeting abstract
- Open Access
Running the hypothesis of a bio molecular approach to psychiatric disorder characterization and fatty acids therapeutical choices
© Cocchi and Tonello; licensee BioMed Central Ltd. 2009
- Published: 22 April 2010
- Arachidonic Acid
- Protein Status
- Neuronal Signalling
- Therapeutical Choice
- Membrane Dynamic
Beyond the conviction that Major Depression can found its origin in genetics [1–3] a bio molecular mechanism could be hypothesized from what emerged from the studies on platelets fatty acid composition in human (normal and depressive subjects) which allowed classifying the depressive disorder  using an Artificial Neural Network (Self Organizing Map-SOM) , as mathematical tool, because of the complexity of the membrane dynamics.
There are strong reasons to think that each fatty acid combination of Palmitic Acid (PA), Linoleic Acid (LA) and Arachidonic Acid (AA), in platelet, is responsible of the membrane viscosity and, therefore, of the molecular conditioning of the cellular stuctures (Gsα and Tubulin) and that the main therapeutic target is the reduction of the Arachidonic Acid.
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