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Anxiety and depression among Greek men with primary erectile dysfunction and premature ejaculation
Annals of General Psychiatry volume 14, Article number: 34 (2015)
Erectile dysfunction (ED) and premature ejaculation (PE) are the two most prevalent sexual disorders among males associated with significant distress and impairment in quality of life. The aim of this study was to investigate the prevalence of anxiety and depression symptoms among patients with primary ED and PE.
A sample of 57 men (ED = 31; PE = 26) were compared to 25 male outpatients with anxiety disorder (AD) and 25 healthy controls. Principal assessment measures included the State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI).
Greater levels of STAI state anxiety were reported among the ED, PE, and AD groups as compared to healthy controls. In contrast ED and AD groups scored higher than controls on the STAI trait anxiety and BDI, but PE scores were not different from healthy controls in both measures.
The study findings suggest that both primary ED and PE are conditions associated with significant state anxiety; however, PE appears to be less associated with trait anxiety and depression compared to ED, a finding that corroborates the recent acknowledgement of PE as a more biologically based condition. Limitations and potential clinical implications are also discussed.
Sexual dysfunction is characterized by disturbances during any stage of the sexual response cycle. It is a common, yet debilitating, condition affecting both men and women at some point in their lives and preventing them from experiencing satisfaction from the sexual activity . Among men, the two most prevalent sexual complaints are erectile dysfunction (ED) and premature ejaculation (PE) .
ED is defined as persistent inability to achieve and maintain an erection sufficient for satisfactory sexual performance . It is estimated to affect up to 52 % of men globally, of whom 5–20 % experience moderate to severe ED symptoms [4–6]. PE is defined as persistent ejaculation with minimal sexual stimulation before or soon after penetration, in which the individual has minimal voluntary control over . It is a highly common condition, with prevalence rates reported in epidemiological studies as high as of 30 % [6, 8–12]. Both disorders can be profoundly disabling, causing long-lasting adverse effects on self-image, significant interpersonal and intimacy difficulties [3, 13–15], and mental health problems [13–15].
It has long been thought that sexual disorders, including ED and PE, are primarily due to psychological factors. Anxiety and depression in specific are considered to play a major role in the development and maintenance of problems related to sexual functioning [16, 17]. Several studies have identified an association between anxiety and ED [18–21], as well as anxiety and PE [22, 23], although some studies have found that anxiety may in fact facilitate sexual arousal [17, 24]. A strong association exists between depression and ED and the strength of that relationship increases with the severity of depression [25, 26]. Depression has also been linked to PE [9, 27], with recent findings showing that this relationship increases with the duration of PE .
Recent studies have pointed out that ED and PE may be differentially affected by anxiety and depression symptoms. For instance, genetic rather than psychological factors are increasingly recognized as important contributors to the development of PE , while performance and free-floating anxiety appear to play a crucial role on the development and sustenance of ED . To our knowledge, there are no studies that directly compare patients with ED and PE on anxiety and depression symptoms. In addition, very few studies have investigated sexual disorders among Greek males .
The study attempts to fill this important gap in the literature by investigating whether ED and PE patients differ in terms of state and trait anxiety and depression symptoms. To make meaningful comparisons between these two groups, two additional groups were included; one of healthy controls and one group of outpatients with anxiety disorder. Based on prior research evidence, we hypothesized that patients with ED and PE will report STAI and BDI scores higher than healthy controls, but comparable to AD patients; we also hypothesized that there will be differences in trait (but not state) STAI and BDI scores between ED and PE patients.
The clarification of the relationship between male sexual disorders and anxiety and depression is essential for proper assessment and treatment of ED and PE; by understanding better the role of anxiety and depression in the development and maintenance of male sexual disorders, clinicians will be able to design and implement interventions tailored to their patients’ specific needs.
The study was approved by the Ethics Committee of Eginition Hospital in Athens, Greece. The total sample consisted of 107 male participants: 57 outpatients diagnosed with sexual dysfunction, 25 outpatients diagnosed with anxiety disorders, and 25 healthy controls, described in detail below.
Sexual dysfunction group Participants in the sexual dysfunction group were recruited from the Outpatient Specialty Clinic for Sexual Disorders of Eginition Hospital in the Department of Psychiatry of the Medical School of Athens between September 2010 and July 2014. The clinic is part of a large, inner city psychiatric hospital and treats a diverse patient population seeking help for a wide range of psychosexual problems, commonly referred to the clinic by either a medical professional (e.g., urologist, general practitioner) or telephone helplines offering support and counseling for sexual problems. Eligible participants in this study were adult, heterosexual men with an exclusive diagnosis of primary (lifelong) ED or PE according to the Diagnostic and Statistical Manual of Mental Disorders—4th Edition (DSM-IV-TR) criteria , confirmed by the Mini International Neuropsychiatric Interview (MINI) .
Prior to participation in the study, all eligible participants had undergone a comprehensive andrological diagnostic workup, which included obtaining detailed medical history, physical examination, and hormonal evaluation to rule out organicity of reported sexual problems. Organic ED was ruled out by confirming the presence of morning or situational (e.g., masturbatory) erections. Other exclusion criteria were (a) medical conditions interfering with sexual function; (b) medications affecting sexual function administered within 30 days before screening; (c) alcohol or substance abuse; (d) presence of major psychiatric disorder and/or suicide risk. Fifty-seven patients meeting the above criteria agreed to enroll in the study by signing an informed consent; 31 (54 %) were diagnosed with primary ED and 26 (46 %) with primary PE.
Anxiety disorder group The anxiety group included 25 adult male outpatients who were evaluated in the Behavioral Treatment Unit at the Department of Psychiatry of the University of Athens Medical School and met criteria for an anxiety disorder according to DSM-IV-TR . Diagnoses included obsessive compulsive disorder (N = 8), panic disorder (N = 14), and generalized anxiety disorder (N = 3). Participants had to be between ages 18 and 65 with no diagnosis of sexual disorder as assessed by the initial psychiatric assessment conducted at the clinic and further confirmed by the International Index of Erectile Function Questionnaire (IIEF) . None of the participants received pharmacological or psychosocial treatment at the time of data collection, as they had just completed evaluation and were awaiting treatment placement.
Control group The control group included 25 healthy men who were opportunistically recruited from friends or relatives of the hospital personnel (75 % participation rate). Exclusion criteria were diagnosis of sexual dysfunction or any psychiatric disorder as assessed by the IIEF  which is further described below.
Procedure and measures
The study was conducted at Eginition Hospital between 2010 and 2014. The study was in accordance with the protocol and ethical principles stated in the Declaration of Helsinki and approved by the Ethics Committee of Eginition Hospital. Following a complete description of the study, written informed consent was obtained from all participants. Information about age, marital status and educational level of the participants was obtained through a self-report demographic questionnaire. The following standardized scales were administered to measure key concepts for the study.
State-trait anxiety inventory (STAI) . Anxiety symptoms were measured with STAI, a self-administered scale consisting of 40 questions rated on a four-point Likert-type scale from “Almost Never” to “Almost Always” with higher scores indicating greater anxiety. STAI provides scores for two 20-item subscales, one for state anxiety, i.e., the level of anxiety experienced at the time of assessment, and one for trait anxiety, i.e., the more general, pervasive and longstanding tendency for experiencing anxiety. The STAI (Form Y) has been translated in Greek and validated in the Greek population with adequate psychometric properties .
Beck depression inventory (BDI) . Depression symptoms were measured with the BDI, which is a self-administered 21-item questionnaire of neurovegetative and cognitive–emotional symptoms of depression. BDI is used both for the screening of depression and assessment of severity of depressive symptomatology. BDI has been translated and validated for use in the Greek population .
International Index of Erectile Function Questionnaire (IIEF) . Sexual function was measured with IIEF, a brief, self-administered scale that consists of 15 questions assessing five domains of male sexual function: erectile function (six items), orgasmic function (two items), sexual desire (two items), intercourse satisfaction (three items), and overall satisfaction (two items). Scores are calculated for the 5 domains as well as for the Total Index score, with higher scores indicating better sexual functioning.
Life events Life events were assessed by a short, self-administered questionnaire especially devised for the present study. The questionnaire contained a list of 18 life events commonly reported in this population, covering the areas of personal, family, work, and social life, which have occurred over the last year.
Continuous variables are presented with mean and standard deviation (SD) or with median and interquartile range (IQR). Qualitative variables are presented with absolute and relative frequencies. Fisher’s exact test was used for the comparison of proportion. Analysis of variance (ANOVA) was performed to compare age between the four study groups. For the comparison of life events between the four groups the Kruskal–Wallis test was used. Univariate linear regression analyses were conducted to explore differences in state, trait, and depression between the four study groups. Afterwards, multiple linear regression analyses were performed to explore the differences found in univariate analysis after adjusting for age, family status and number of life events that the subjects had experienced. Regression coefficients and standard errors were computed from the results of the linear regression analyses. Diagnostics for regression models were performed to check if the conditions for regression had been met with the residuals of each model being normally distributed and their variance being constant. Interactions of variables in the models were not significant. All reported p values are two tailed. Statistical significance was set at p <0.05 and analyses were conducted using SPSS statistical software (version 19.0).
The sample consisted of 107 participants (31 in the ED group, 26 in the PE group, 25 in the AD group, and 25 healthy controls) with mean age 36.3 years (SD = 10.6 years). The four groups were comparable in terms of age and family status. Sample demographic characteristics and number of life events are presented in Table 1. The median number of life events overall, as well as those related to economic issues, was similar between the four groups (p > 0.05). Table 2 illustrates the mean scores on STAI and BDI scores for the four study groups.
Results from univariate and multiple regression models investigating group differences in state/trait and BDI scores are presented in Table 3. Both univariate and multiple analyses showed significantly greater levels of state anxiety in the ED, PE, and AD groups as compared to healthy controls. No significant differences in state anxiety scores were found between the ED and PE groups, or between the AD group versus ED and PE groups, suggesting that all three clinical groups endorsed equivalent levels of state anxiety.
Regarding the trait anxiety scores, while significant differences were observed between healthy controls and the ED group (p < 0.05) and the AD group (p < 0.001), there was no difference between controls and the PE group (p > 0.05). Both ED and PE groups reported significantly lower trait anxiety scores than the AD group. Participants in the PE group scored lower on the trait anxiety scale than their ED counterparts, but the difference did not reach statistical significance. With regard to depression symptoms, both AD and ED groups scored significantly higher on the BDI compared to healthy controls. A trend towards higher BDI scores than controls was noticed for the PE group. No significant BDI score differences were found between AD group and ED or PE groups.
The aim of this study was to investigate the prevalence of state and trait anxiety and depression in primary ED and PE. To draw meaningful conclusions, we included a group of anxious patients and a group of healthy controls.
Our results provide evidence for the differential role of anxiety and depression in primary ED and PE. Both sexual dysfunction groups endorsed higher state anxiety scores compared to healthy controls, but lower than patients with ADs. Interestingly, the results for the trait anxiety were different. As expected, both sexual dysfunction groups reported lower trait anxiety. However, ED patients had significantly higher scores than healthy controls, unlike the PE group which scored comparably to the control group. Similarly, our results showed that ED patients scored higher than controls in depression as measured by the BDI, while scores among the PE group were not different from controls.
Our results on state anxiety, indicating that all clinical groups (ED, PE, and AD) had significantly higher state anxiety compared to healthy controls, are in agreement with previous research findings. For instance, a recent study with 882 ED and PE patients found that both PE and ED groups were associated with excess of free-floating anxiety . While the levels of state anxiety are equivalent among the three groups, the type of situational anxiety triggered in each clinical group is hypothesized to be different. In ADs, situational anxiety arises as a response to selective attention to threat information coupled with a distorted cognitive processing of the situation (i.e., catastrophic misappraisal). For example, in panic disorder, attention is selectively directed toward somatic symptoms which are assessed as dangerous, while in generalized anxiety disorder, attention is focused on external danger triggering ruminative thoughts regarding the impending disaster and its potential prevention .
In sexual dysfunctions, anxiety, and stress reactions in general are viewed as cognitive interferences that distract attention from sexual stimuli thus inhibiting sexual arousal. The situational stress in sexual dysfunctions may take the form of “performance anxiety” [38, 39]. This anxiety appears to interfere with sexual functioning through altering the neural substrate of sexual behavior, further contributing to the maintenance of sexual dysfunctions. The performance anxiety affects the normal sexual functioning through selective attention [40–42].
Erection concern thoughts reduce sexual arousal and intervene with normal sexual functioning . These thoughts are automatic in nature and focus on sexual performance (e.g., “my penis is not responding” “why can’t it work”?). These cognitions are accompanied by selective focus on erectile response and the negative consequences of a possible sexual “failure”, thus impairing the processing of sexual stimuli, reducing the frequency of sexual fantasies and increasing negative emotions (e.g., sadness, shame) . The selective focus on sexual performance and the possible negative consequences of failure, combined with the absence of sexual thoughts and depressed mood further reinforce the cycle of sexual difficulties and mood problems [38, 43, 44].
Moreover, Nobre  focuses on a particular belief that seems to play a dominant role in erectile dysfunction, namely the “macho myth” (i.e., myth of the male role), which seems to result in rigid beliefs and expectations about sexual performance. Examples of such rigid beliefs include “I have to have frequent sexual activities”, “I need to be able to satisfy any partner”, or “it is necessary to maintain my erection under any circumstance”. Such rigid attitudes and expectations regarding sexual performance render men more susceptible to have a negative schema of inadequacy triggered when exposed to an “unsuccessful” sexual experience .
Clinical practice reveals a plethora of negative thoughts that could lead to state anxiety and subsequent sexual dysfunction, such as feeling “trapped”, or fearing that the partner “will break up” with or “cheat on” the individual. In addition, several other factors play an important role in sexual dysfunction, including emotional expression and proximity in the paternal family, presence of potentially traumatic sexual experiences, and religious beliefs . Also, social messages through media can influence and shape the modern perception of sexuality and prescribed male and female sexual roles, often promoting a “vulnerable” sexual culture .
Our study findings regarding trait anxiety revealed a different pattern. Not surprisingly, trait anxiety was found to be significantly higher among individuals with anxiety disorders compared to all three other groups. Indeed, the strong association between anxiety disorders and trait anxiety is well supported in the literature . However, the finding that ED patients—but not PE—scored higher in trait anxiety compared to healthy controls has interesting implications. Stated differently, patients with PE had comparable trait anxiety scores to healthy controls. Taken together, these findings are in agreement with contemporary research evidence suggesting that organic, neurobiological rather than psychological factors are implicated in the development of primary PE [47, 48].
A similar pattern was observed for depression symptoms. Again, AD patients scored the highest among the three clinical groups, whereas ED but not PE patients scored significantly higher on the BDI than controls. This result echoes previous research findings showing that depression is a risk factor for ED but not for PE [49, 50]. Several studies have identified a high comorbidity between depression and ED [51–56] but the directionality of this relationship has yet to be determined [57, 58]. It may be that depression symptoms hinder sexual arousal and impair erectile function, or vice versa; the presence of erectile difficulties may trigger low mood building up to the development of depressive syndrome [51, 52]. On the contrary, patients with PE are less likely to experience depression symptoms, a finding that further supports the neurobiological nature of the disorder possibly influenced by hereditary factors [44, 59].
Of note, the average number of life events involving economic problems and the average number of all other life events did not differ significantly among the four groups. This finding suggests that, in the present study, economic problems were not a risk factor for sexual dysfunction. Absence of relationship between life events (financial) and PE corroborates previous findings . However, this finding must be interpreted with caution, as data collection of this study took place amidst a period of significant economic hardship due to the Greek financial crisis that affected the majority of the Greek population. Thus, the lack of significant relationship between financial stressors and sexual dysfunction may be attributable to the broader economic context in Greece.
The study has several limitations that merit acknowledgment. The most obvious limitation is the cross-sectional design of the study that does not allow an investigation of causality. Any causal relationships between anxiety and sexual dysfunctions must be explored in prospective studies. Moreover, all measurement tools employed in this study were self-report in nature. Another limitation pertains to the clinical sample of the study that may limit the study’s generalizability to the general population. Finally, our study focused on primary ED and PE patients and thus our results may not be generalizable to patients with sexual dysfunctions acquired later on in their lives. Among the strengths of this study is that it investigates an important subject largely ignored in the literature and it is conducted in the largely understudied population of White Greek patients.
The significant clinical differences between ED and PE in terms of anxiety and depression suggest that these two sexual disorder groups may warrant different types of treatment. Compared to ED, PE appears to be less vulnerable to mood and anxiety symptoms and possibly more biologically determined. These findings, which nevertheless await to be confirmed in larger and more robust future studies, may have considerable implications for clinical practice. Mental health practitioners working with male sexual disorders may need to conduct thorough assessment and tailor their treatment plan accordingly to match the different needs of these two groups. Patients with ED may benefit from interventions targeted on modifying core schemas (i.e., “failure”) and beliefs (i.e., “macho myth”) accompanying the disorder. Another effective psychosocial intervention is stress management; a recent study with 31 Greek men with a recent diagnosis of ED found that an 8-week stress management program was effective as an adjunct to tadalafil for the treatment of ED . In contrast, in the case of PE, practitioners should place greater emphasis on neurophysiological contributors of the disorder and determine when it is necessary to refer patients to specialized care.
To conclude, individuals with primary ED and PE showed comparable levels of state but not trait anxiety or depression symptoms. Results provide support for the central role of neurobiological and genetic factors over psychological factors as the underlying causal mechanism of PE and point towards a differential treatment of the disorders.
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IM (Principal Investigator, Clinical Head of Sexual Disorders Clinic) conceived of the study, designed and carried out the study, participated in data collection and statistical analysis and drafted the manuscript. This work is part of his doctoral dissertation. GP, NV and IZ supervised the design of the study, data collection, and statistical analysis. CT participated in the design of the study and performed the statistical analysis. MA was the clinical coordinator of the study and participated in data collection and management, and manuscript preparation. EM was the patient coordinator of the study and participated in data collection and management, and manuscript preparation. CE was the assistant clinical coordinator of the study and participated in manuscript preparation. EV participated in statistical analysis and manuscript preparation. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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Mourikis, I., Antoniou, M., Matsouka, E. et al. Anxiety and depression among Greek men with primary erectile dysfunction and premature ejaculation. Ann Gen Psychiatry 14, 34 (2015) doi:10.1186/s12991-015-0074-y
- Sexual dysfunction
- Erectile dysfunction
- Premature ejaculation