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Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors
Annals of General Psychiatry volume 15, Article number: 25 (2016)
Quality of life can be perceived as a subjective assessment of different aspects of human functioning. Personality is a factor which determines actions taken by individuals and their tendency to perceive reality in a particular way. Therefore, the assumption that personality may influence the QoL assessment seems reasonable. Our purpose was to assess the relationships between personality traits and the presence of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. We also wanted to determine the influence of personality on the quality of life of postmenopausal women.
The study involved 214 postmenopausal women from northwest Poland. It was conducted using the NEO-FFI and the SF-36 questionnaires. DNA polymorphisms were identified using the polymerase chain reaction (PCR).
The average age of the women was 56.8 ± 4.08 years. Half of the respondents had completed second-level education, 69.2 % had life partners, and 53.3 % were professionally active. Women with the 3/3 genotype were characterized by significantly lower openness to experience than respondents with other MAO-A genotypes (p < 0.05). There was a significant correlation between the quality of life and the levels of neuroticism and extroversion, as well as between selected quality of life domains and the levels of agreeableness and conscientiousness.
(1)Women with the 3/3 genotype of the 30-bp VNTR polymorphism in the MAO-A promoter region are characterized by lower levels of openness to experience than women with other MAO-A genotypes in our study (2) Personality traits may contribute to the assessment of the quality of life.
The postmenopausal period is a special time in a woman’s life—the time which entails progressive deterioration in the quality of life, leading as a consequence to lower physical activity, withdrawal from social life and unwillingness to develop. When analyzing inconveniences of the perimenopausal period, special attention should be paid to the fact that as many as 90 % of women suffer from mental disorders manifested by sudden mood changes, difficulties in coping with stress in everyday life, depressed mood, getting tired quickly, restlessness and irritation, as well as concentration problems, the weakening of memory, treatment unresponsive somatic complaints, and full-blown depression [1, 2]. The mechanism of developing mental disorders in the perimenopausal period has not been so far fully elucidated. It has not been unambiguously established whether lower mood, tension, and concentration problems are associated with changes in hormone metabolism, or whether they result from the configuration of psychosocial factors. A decline in the estrogen level results in vasomotor symptoms—such as hot flushes, sweats, and headache—which negatively affect the quality of women’s lives, causing sleep and concentration problems, oversensitivity, fatigue, and melancholy . According to some reports, depression occurs mainly in those perimenopausal women who are predisposed to it and who have already experienced depressive episodes. The level of estrogen may contribute to depressive symptoms in the early stages of menopause, which suggests that a sudden drop in the estrogen level increases a risk of depressive disorders. It would explain the lack of relationship between depression and gradually decreasing estrogen levels in postmenopausal women. Depression in the postmenopausal period seems to have different aetiology [4, 5]. It is believed that the monoamine imbalance, which modifies the expression of traits, mental functions and behaviour, may contribute to mood disorders . Scientists identified genes that may have the most profound effects on the metabolism of monoamine neurotransmitters, such as serotonin (5-HT) and monoamine oxidase A (MAO-A). The expression of these genes depends on the type of polymorphism potentially contributing to the occurrence of specific mood disorders. The serotonin transporter (5-HTT) gene (SLC 6A4) polymorphism is characterized by the insertion or deletion of a 44-bp fragment, and thus, the creation of the long (l) allele and the short (s) allele. The presence of the ‘s’ allele of the 5-HTT gene is presumably associated with a lower gene expression and worse functioning of the serotonin transporter, which in turn disturbs neurotransmission and results in a higher tendency to anxiety and avoidant behaviours [7, 8]. It has also been proved that the ‘s’ allele involves lower serotonergic flexibility and as a consequence impulsive behaviours . MAO-A is an enzyme involved in the degradation of biogenic amines. Until now, researchers have mainly focused on the functional VNTR polymorphism in the promoter region of the gene encoding this enzyme. It consists of a 30-bp repeated sequence that may be present in 3, 3.5, 4, or 5 copies. The ‘3’ allele is associated with a lower, and the ‘3.5’, ‘4’, and ‘5’ alleles—with a higher gene transcriptional activity. The MAO-A gene may be responsible for an inclination to depression .
Based on analysis of the correlations between personality traits of monozygotic and dizygotic twins, and the phenomenon of sharing personality traits with brothers and sisters in biological and adoptive families, behavioural geneticists proved that the occurrence of similar personality traits within one family is determined by genetic factors. Personality consists of several dimensions or characteristics, which have a normal distribution in the general population. Personality is defined as an individual’s unique behavioural pattern. There are significant interindividual differences in reacting to changes in the external and internal environment. According to McCrae and Costa there are five personality dimensions: Neuroticism, Extroversion, Openness to experience, Agreeableness, and Conscientiousness .
At present, quality of life is the most dynamically developing and increasingly described measure of health. It defines the level of self-realization and satisfaction with life from a holistic perspective . In the case of perimenopausal women, several aspects of QoL can be discussed, namely the subjective perception of one’s position in life, health status, as well as physiological changes and their consequences [13–15]. Somatic and psychological complaints usually change people’s views of their QoL. Currently, a lot of attention is devoted to the concept of health-related quality of life (HRQoL), which covers four domains: physical functioning, mental functioning, social functioning, and symptoms associated with the pathological and therapeutic processes. Self-reported QoL may change with time and under the influence of objective factors [16, 17]. Personality significantly determines the QoL assessment both among healthy patients, and those with somatic and/or mental disorders .
The purpose of this study was to determine how personality traits of postmenopausal women are related to the presence of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. We wanted also to establish the influence of personality on self-reported quality of life.
Our research involved 214 healthy women, living in northwest Poland. All participants gave informed consent to take part in the study and their anonymity was preserved. The inclusion criteria were at least 1 year after the last menstruation, no alcohol abuse, no smoking, no endocrine disorders, no neoplastic diseases, and no current or past history of psychiatric treatment. To exclude mental disorders in the study group, all women were screened by means of the Primary Care Evaluation of Mental Disorders Patient Heath Questionnaire 9 (PRIME-MD PHQ-9) prior to the study. The PRIME-MD questionnaire concerns all criteria for depression diagnosis, and includes a gradual scale for measuring the severity of symptoms.
The first stage of the study was based on a survey performed using standard research instruments, namely the Neuroticism-Extroversion-Openness-Five Factor Inventory (NEO-FFI) and the Short Form Health Survey (SF-36) for measuring quality of life. The NEO-FFI is applied to analyze personality traits included in the Five Factor Model. The questionnaire consists of five scales measuring: neuroticism, extroversion, openness to experience, agreeableness and conscientiousness. Sixty self-descriptive statements are answered on a five-point scale. The points obtained for each of the NEO-FFI scales are summed up, thus giving the score: high (7–10), average (4–6), or low (1–3) for each of the five scales. The questionnaire was adapted into Polish by Bogdan Zawadzki, Jan Strelau, Piotr Szczepaniak, and Magdalena Śliwińska in 1998. The Short Form Health Survey (SF-36) serves for measuring quality of life. It consists of 11 questions, including 36 statements, divided into subscales measuring eight aspects of QoL, namely physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health.
The second stage of the study was based on genetic tests. For genetic analysis 10 ml venous blood samples were collected with the Vacutainer. Biological material (blood) was collected and stored in accordance with the principles of the quality management system of the Genetic Laboratory, the Department of Psychiatry. DNA was isolated from whole blood by the salting-out method of Miller. Polymerase chain reaction (PCR) was used to identify DNA polymorphisms. The aim of the analysis was to amplify the fragment consisting of 2–5 repetitions of the 30-bp VNTR polymorphism in the MAO-A promoter region. The following primer sequences were used: MAO-A F: 5′ CCC AGG CTG CTC CAG AAA 3′, and MAO-A R: 5′ GGA CCT GGG CAG TTG TGC 3′. The sizes of the amplified fragments were as follows: 239, 209, 226, and 269 bp. In the 5HTT polymorphism analysis, the fragment—including the 44-bp ins/del in the regulatory sequence (the presence or lack of 44-bp)—was amplified. The following primer sequences were used: HTT F: 5′ GGC GTT GCC GCT CTG AAT GC 3′, and HTT R: 5′ GAG GGA CTG AGC TGG ACA ACC AC 3′. The sizes of the amplified fragments were 484 and 528 bp.
Statistical analysis was performed using Statistica 7.1 PL. The following tests were applied: the Chi square independence test, the Kruskal–Wallis test, Pearson’s linear correlation coefficient, and the multiple comparison test, showing which groups differ from each other if the Kruskal–Wallis test demonstrated significant differences between at least two groups. The significance level was set at α = 0.05. The gene polymorphisms did not show significant deviations from Hardy–Weinberg’s Equilibrium. The study described in the article has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) and was approved by the Bioethical Commission of the Pomeranian Medical University in Szczecin, Poland (Permission Number KB-0012/155/13).
The mean age of the women was 56.8 ± 4.08 years. Nearly half of them (47.7 %) had secondary education, 36.4 %—higher education. The majority of the respondents lived in cities with a population of more than 100,000 residents (61.7 %). Most women in the study (69.2 %) had life partners. Greater than half of the respondents (53.3 %) were professionally active. Low and medium levels of neuroticism were noted in 77.9 % of the women, and high levels in 22.1 %. About half of the women had medium levels and about 40 %—high levels of extroversion, agreeableness and conscientiousness. Medium levels of openness to experience were observed in 41.5 % of the respondents and high levels in 46.9 %.
Furthermore, we evaluated quality of life using the SF-36 questionnaire. The highest scores were obtained on physical functioning (79.07 ± 19.43), emotional functioning (74.84 ± 38.85), and social functioning (74.64 ± 23.31). The lowest scores were obtained on the vitality domain (57.26 ± 15.19), role physical (57.32 ± 42.92), and on general health (59.57 ± 18.66).
The results were statistically analysed with regard to the genotype distribution of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region and the expression of personality traits according to the NEO-FFI. The analysis conducted using the Kruskal–Wallis test did not reveal any statistically significant differences (Table 1).
Similarly, the statistical analysis conducted using the Kruskal–Wallis test with regard to the genotype distribution of the 30-bp VNTR polymorphism in the MAO-A promoter region and the levels of personality traits according to the NEO-FFI demonstrated that the genotype distribution of the 30-bp VNTR polymorphism in the MAO-A promoter region had significant effects on the level of openness to experience (p < 0.05) (Table 1). Further analysis based on the test of multiple comparisons showed that women with the 3/3 genotype were characterized by significantly lower levels of openness to experience than respondents with other MAO-A genotypes (p < 0.05) (Table 2).
We analyzed the influence of personality traits on the QoL of the surveyed, and found that the levels of neuroticism and extroversion positively correlated with all SF-36 QoL domains. We also observed a positive correlation between the level of agreeableness and all SF-36 QoL domains, except for the bodily pain domain, and positive correlations between the level of conscientiousness and the domains of physical functioning, vitality, social functioning, role emotional, and mental health. There was no statistically significant correlation between the women’s QoL and the openness to experience level (Table 3).
Numerous studies conducted so far confirm the influence of genetic factors on personality. Many of them describe the role that the MAO-A gene polymorphisms play in the evolution of personality traits. The analysis of 277 women and men, performed by Chester et al., demonstrated that the presence of the low activity MAO-A predisposes to aggressive behaviour and acting on negative impulses . According to Caspi et al., individuals with the low-activity MAO-A genotype who were hurt and maltreated in their childhood significantly more often develop conduct disorders and display antisocial behaviour than their counterparts with the high-activity MAO-A genotype . These findings were supported by Foley et al. and Nilsson et al. [21, 22]. Other researchers assert that people with the low-activity MAO-A and the 5-HTTLPR l/l genotype are less impulsive than those with the low-activity MAO-A and the s/s genotype . It was also found that men with the low activity MAO-A gene have higher levels of neuroticism , and women with the high activity MAO-A have higher levels of anxiety and suffer from more severe depression [25, 26]. Additionally, there are reports that the MAO-A genotype contributes to the occurrence of antisocial behaviour among female teenagers with alcohol problems . Our study did not provide evidence for the impact of the investigated gene polymorphisms on the levels of personality traits. The only exception was the 3/3 genotype of the 30-bp VNTR polymorphism in the MAO-A promoter region, whose presence contributed to a higher openness to experience level.
The presence of the ‘s’ allele of the 5-HTT gene may be associated with a higher tendency to anxiety, as well as avoidant and impulsive behaviour [7–9]. The study based on magnetic resonance imaging (MRI) demonstrated that carriers of one or two low transcriptional activity alleles (the s/s or s/l genotype) had higher neuronal activity of the amygdala responsible for negative emotions, aggression, and defence reactions in response to stressful life events, than their counterparts with a higher transcriptional activity allele (the l/l genotype) . Some researchers claim that girls carrying the ‘s’ allele and getting no support from their families more often behave without inhibitions and engage in impetuous and ill-considered actions. At the same time, family relationships were proved to have no influence on the occurrence of impulsive behaviours in girls with the ‘l’ allele . Our study did not reveal any statistically significant differences in the genotype distribution of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region depending on the levels of personality traits as gauged by the NEO-FFI. Similar results were obtained by Stein et al., who searched for the connection between the 5-HTTLPR gene polymorphism and the level of neuroticism (a statistically significant relationship was not demonstrated) . Gingnell et al. reported that high neuroticism was more common among women suffering from premenstrual dysphoric disorder (PMDD) than in the group of healthy females. What is more, anxiety and the lack of assertiveness were more common among women with the ‘s’ allele than those with the ‘l’ allele . Jacob et al. found that the levels of neuroticism were higher in a group of patients with type C personality disorders who carried the ‘s’ allele than in those without this allele. The study did not reveal differences in the distribution of the 5-HTT genotypes between respondents with types A and B personality disorders and those in the control group .
There is no doubt that the quality of women’s lives deteriorates in the perimenopausal period. The contribution of climacteric symptoms to a decline in the quality of life (especially psychosocial, physical and sexual spheres) has been confirmed by many studies [32, 33]. Little attention has been so far paid to personality, which undoubtedly plays a role in the QoL assessment. Van Straten et al. used the SF-36 questionnaire to measure the QoL of 640 outpatients with mood and anxiety disorders with regard to personality factors. They found that all personality traits according to the NEO-FFI, except for conscientiousness, were closely related to the QoL. The level of agreeableness was related to the assessment of physical and social domains, while the levels of neuroticism, extroversion, and openness to experience were related to mental domain. The low QoL level was not only associated with mood and anxiety disorders but also these personality traits which are relatively stable throughout life . In the study of 442 primary care patients, aged 65 years or more, conducted using the NEO-FFI and the SF-36, high levels of neuroticism were accompanied by lower QoL in the physical sphere. High levels of conscientiousness, on the other hand, were associated with higher SF-36 scores . The study of over 5000 adults, aged 50 years, carried out by Cheng et al. revealed a significant relationship between personality traits and the QoL assessment . Extroversion and conscientiousness were significantly related to the QoL in the study group. Besiland et al. analysed factors contributing to the QoL of 260 patients after surgical treatment for kidney cancer. In this analysis, the QoL was the lowest assessed by patients with neurotic personality and avoidant attitudes .
In our study, neuroticism and extroversion affected all QoL domains, agreeableness influenced all domains except for bodily pain, and conscientiousness had effects on all domains except for physical functioning, general health and vitality. There was no relationship between QoL and openness to experience.
Quality of life can be perceived as a subjective assessment of different aspects of human functioning. Personality is a factor which determines actions taken by individuals and their tendency to perceive reality in a particular way. Therefore, the assumption that personality may influence the QoL assessment seems reasonable. Our findings confirm that personality traits have effects on various QoL aspects. Based on our results and those reported by other authors, it can be asserted that QoL does not depend exclusively on health status and life situation, but also personality traits which are relatively stable throughout life.
Women with the 3/3 genotype of the 30-bp VNTR polymorphism in the MAO-A promoter region are characterized by lower levels of openness to experience than women with other MAO-A genotypes in our study.
Personality traits may contribute to the assessment of the quality of life.
Our findings suggest that either monoamine imbalance—associated with the presence of the 30-bp VNTR polymorphism in the MAO-A promoter region and the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region—has no influence on the QoL of postmenopausal women, or the relationships between these polymorphisms, QoL, and personality traits were not observed because the study involved only healthy women (those with mental disorders were excluded).
The size of the study sample does not let us draw the conclusions for the whole population.
Another limitation of the study is the lack of personality assessment according to the Structured Clinical Interview for DSM-IV Disorders (SCID), which would allow us to make the major DSM-IV Axis I diagnosis.
a multidimensional coping inventory to assess the different ways in which people respond to stress
European organization for research and treatment of cancer quality of life questionnaire
monoamine oxidase A
menopausal hormone therapy
neuroticism-extraversion-openness five-factor inventory
polymerase chain reaction
primary care evaluation of mental disorders patient health questionnaire 9
short form health survey
solute carrier family 6 member 4
temperament and character inventory
variable number of tandem repeats
World Health Organization quality of life-bref
Orzechowska A, Typel D, Wysokiński A, Talarowsk-Bogusz M, Gruszczyński W. Funkcjonowanie psychospołeczne kobiet w okresie klimakterium [Psychosocial functioning of women in the climacteric period]. Psychiatr Pol. 2007;3:293.
Sprawka K, Wysokiński A, Orzechowska A, Talarowska- Bogusz M, Typel D, Gruszczyński W. Zaburzenia depresyjne i lękowe w okresie klimakterium [Depressive and anxiety disorders in the climacteric period]. Psychiatria. 2008;5:99–104.
Llaneza P, García-Portilla MP, Llaneza-Suárez D, Armott B, Pérez-López FR. Depressive disorders and the menopause transition. Maturitas. 2012. doi:10.1016/j.maturitas.2011.11.017.
Freeman EW, Sammel MD, Liu L, Gracia CR, Nelson DB, Hollander L. Hormones and menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatr. 2004;61:62–70.
Woods NF, Smith-DiJulio K, Percival DB, Tao EY, Mariella A, Mitchell S. Depressed mood during the menopausal transition and early postmenopause: observations from the Seattle midlife women’s health study. Menopause. 2008;15:223–32.
Jabbi M, Krof J, Kema IP, Hartman C, van der Pompe C, Minderaa RB, et al. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAO-A. Mol Psychiatr. 2007. doi:10.1038/sj.mp.4001975.
Stein MB, Campbell-Sills L, Gelernter J. Genetic variation in 5HTTLPR is associated with emotional resilience. Am J Med Genet Part.B Neuro Psychiatr Genet. 2009. doi:10.1002/ajmg.b.30916.
Jakubczyk A, Wojnar M. Genetyczne i psychospołeczne uwarunkowania impulsywności. Postępy Psychiatrii i Neurologii. 2010;19(1):39–45.
Lesch KP, Gutknecht L. Pharmacogenetics of the serotonin transporter. Prog Neuro psychopharmacol Biol Psychiatr. 2005. doi:10.1016/j.pnpbp.2005.03.012.
Hauser J, Dmitrzak–Węglarz M. Leksykon genetyki w psychiatrii. [A lexicon of genetics in psychiatry.] Poznań: Termedia; 2010.
Costa PT, McCrae RR. Age differences in personality structure: a cluster analytic approach. J Gerentol. 1976;31(5):564–70.
de la Cruz MSD, Lai Z, Goodrich DE, Kilbourne AM. Gender differences in health-related quality of life in patients with bipolar disorder. Arch Womens Ment Health. 2013. doi:10.1007/s00737-013-0351-1.
Kolarczyk E. Przesłanki do podjęcia ogólnopolskich badań jakości życia związanej ze zdrowiem fizycznym i psychicznym kobiet w wieku 45–60 lat. Probl Hig Epidemiol. 2009;90(4):484–9.
Veerus P, Fischer K, Howi SL, Karro H, Rahu M, Hemminki E. Sympton reporting and quality of life in the Estonian postmenopausal hormone therapy trial. BMC Womens Health. 2008. doi:10.1186/1472-6874-8-5.
Walczak A, Wiśniewska B. Psychospołeczne aspekty funkcjonowania kobiet w okresie postmenopauzalnym- badania wstępne. Prz Menopauz. 2011;6:474–7.
Jankowska-Polańska B, Polański J. Metody oceny jakości życia w schorzeniach reumatycznych [Methods of measuring quality of life in rheumatic diseases]. Reumatologia. 2014;52(1):69–76.
Sierakowska M, Wróblewska M, Lewko J, Jankowiak B, Kowalczuk K, Sierakowski S, et al. Ocena problemów zdrowotnych pacjentów z chorobą zwyrodnieniową stawów oraz zapotrzebowania na wsparcie i edukację zdrowotną. [Assessment of health problems of patients with degenerative joint disease, and evaluation of the demand for support and health education]. Probl Pieleg. 2011;19(3):353–60.
Yamaoka K, Shigehisa T, Ogoshi K, Watanabe M, Hayashi F, Hayashi C. Health-related quality of life varies with personality types: a comparison among cancer patients, non-cancer patients and healthy individuals in a Japanese population. Qual Life Res. 1998. doi:10.1023/A:1008830509237.
Chester DS, DeWall CN, Derefinko KJ, Estus S, Peters JR, Lynam DR, et al. Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect. Behav Brain Res. 2015. doi:10.1016/j.bbr.2015.01.034.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, et al. Role of genotype in the cycle of violence in maltreated children. Science. 2002. doi:10.1126/science.1072290.
Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, et al. Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch Gen Psychiatr. 2004. doi:10.1001/archpsyc.61.7.738.
Nilsson KW, Sjoberg RL, Damberg M, Leppert J, Ohrvik J, Alm PO, et al. Role of monoamine oxidase a genotype and psychosocial factors in a male adolescent criminal activity. Biol Psychiatr. 2006. doi:10.1016/j.biopsych.2005.06.024.
Paaver M, Nordquist N, Parik J, Harro M, Oreland L, Harro J. Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing. Psychopharmacology. 2007. doi:10.1007/s00213-007-0867-z.
Eley TC, Tahir E, Angleitner A, Harriss K, McClay J, Plomin R, et al. Association analysis of MAOA and COMT with neuroticismassessed by peers. Am J Med Genet B Neuropsychiatr Genet. 2003. doi:10.1002/ajmg.b.20046.
Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, Yang CW. Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology. 2005. doi:10.1038/sj.npp.1300785.
Samochowiec J, Hajduk A, Samochowiec A, Horodnicki J, Stepien G, Grzywacz A, et al. Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatr Res. 2004. doi:10.1016/j.psychres.2004.05.012.
Nilsson KW, Wargelius HL, Sjoberg RL, Leppert J, Orleand L. The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behavior. Drug Alcohol Depend. 2008. doi:10.1016/j.drugalcdep.2007.08.022.
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003. doi:10.1126/science.1083968.
Paaver M, Kurrikoff T, Nordquist N, Oreland L, Harro J. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatr. 2008. doi:10.1016/j.pnpbp.2008.03.021.
Gingnell M, Comasco E, Oreland L, Fredrikson M, Sundström-Poromaa I. Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR. Arch Womens Ment Health. 2010. doi:10.1007/s00737-010-0164-4.
Jacob CP, Strobel A, Hohenbergen K, Ringel T, Gutknecht L, Rief B. Association between allelic variation of serotonin transporter function and neuroticisminanxious cluster C personality disorders. Am J Psychiatr. 2014. doi:10.1176/appi.ajp.161.3.569.
Chedraui P, Hidalgo L, Chavez D, Morocho N, Alvarado M, Huc A. Quality of life among postmenopausal Ecuadorian women participating in a metabolic syndrome screening program. Maturitas. 2007. doi:10.1016/j.maturitas.2006.05.008.
Sierra B, Hidalgo LA, Chedraui PA. Measuring climacteric symptoms in an Ecuadorian population with the Greene climacteric scale. Maturitas. 2005. doi:10.1016/j.maturitas.2004.08.003.
van Straten A, Cuijpers P, van Zuuren FJ, Smits N, Donker M. Personality traits and health-related quality of life in patients with mood and anxiety disorders. Qual Life Res. 2007. doi:10.1007/s11136-006-9124-x.
Chapman B, Duberstein P, Lyness JM. Personality traits, education, and health-related quality of life among older adult primary care patients. J Gerontol. 2007;62(6):343–52.
Cheng H, Green A, Wolpert M, Deighton J, Furnham A. Factors influencing adult quality of life: findings from a nationally representative sample in the UK. Personal Individ Differ. 2014. doi:10.1016/j.paid.2014.04.026.
Beisland E, Beisland Ch, Hjelle KM, Bakke A, Aarstad AKH, Aarstad HJ. Health-related quality of life, personality and choice of coping are related in renal cell carcinoma patients. Scand J Urol. 2014. doi:10.3109/21681805.2014.990051.
DSM conceived and design of the study, performed the statistical analysis, draft the manuscript; AJ participated in performed the statistical analysis and helped to draft the manuscript; AS participated in design of the study; BK participated in performed the statistical analysis; MS participated in design of the study and helped to draft manuscript; AG carried out genetic analysis; EG participated in conceived and design of the study; coordination and helped to draft manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Availability of data and materials
The datasets during and/or analysed during the current study available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The study described in the article has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) and was approved by the Bioethical Commission of the Pomeranian Medical University in Szczecin, Poland (Permission Number KB-0012/155/13). All participants gave informed consent to take part in the study and their anonymity was preserved.
Financial resources for the project and funds for covering the costs to publication come exclusively from the Pomeranian Medical University of Szczecin.
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Schneider-Matyka, D., Jurczak, A., Samochowiec, A. et al. Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors. Ann Gen Psychiatry 15, 25 (2016) doi:10.1186/s12991-016-0110-6
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