- Primary research
- Open Access
Effect of age and disease on bone mass in Japanese patients with schizophrenia
© Sugawara et al; licensee BioMed Central Ltd. 2012
- Received: 11 December 2011
- Accepted: 20 February 2012
- Published: 20 February 2012
There have been a limited number of studies comparing bone mass between patients with schizophrenia and the general population. The aim of this study was to compare the bone mass of schizophrenia patients with that of healthy subjects in Japan.
We recruited patients (n = 362), aged 48.8 ± 15.4 (mean ± SD) years who were diagnosed with schizophrenia or schizoaffective disorder based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Bone mass was measured using quantitative ultrasound densitometry of the calcaneus. The osteosono-assessment index (OSI) was calculated as a function of the speed of sound and the transmission index. For comparative analysis, OSI data from 832 adults who participated in the Iwaki Health Promotion Project 2009 was used as representative of the general community.
Mean OSI values among male schizophrenic patients were lower than those in the general population in the case of individuals aged 40 and older. In females, mean OSI values among schizophrenic patients were lower than those in the general community in those aged 60 and older. In an analysis using the general linear model, a significant interaction was observed between subject groups and age in males.
Older schizophrenic patients exhibit lower bone mass than that observed in the general population. Our data also demonstrate gender and group differences among schizophrenic patients and controls with regard to changes in bone mass associated with aging. These results indicate that intervention programs designed to delay or prevent decreased bone mass in schizophrenic patients might be tailored according to gender.
- bone mass
It has previously been shown that patients taking antipsychotic medications are at greater risk for bone fractures . The onset of schizophrenia typically occurs during adolescence and young adulthood , therefore, the administration of antipsychotic medications generally begins during the same period, during which bone maturation results in peak bone mass.
In previous studies that have considered decreased bone mass in patients with schizophrenia, factors associated with accelerated bone absorption have included polydipsia , use of neuroleptics  and the resulting hyperprolactinemia [5, 6], heavy smoking , poor diet, drug and alcohol abuse , and lack of exercise .
However, to date there have been a limited number of studies [10–12] comparing bone mass between patients with schizophrenia and the general population. It is therefore necessary to accurately examine the nature of bone mass deficiencies in schizophrenic patients in a cross-sectional manner with an age-matched healthy control group for comparison.
In recent years, a quantitative ultrasound (QUS) densitometry technique has been developed for measuring bone mass. The results obtained using QUS are reported to correlate well with those using dual energy x-ray absorptiometry (DXA) . Furthermore, QUS can provide data on the risk for osteoporosis related fractures [14, 15]. QUS is a relatively quick procedure that is inexpensive and does not expose patients to radiation, making it suitable for research projects examining large numbers of subjects .
The aim of this study was to compare bone mass between patients with schizophrenia and healthy individuals using QUS. To the best of our knowledge, this is the largest study of this nature to be carried out in Japan.
The subject pool consisted of 362 patients (178 males and 184 females) who were diagnosed with either schizophrenia or schizoaffective disorder based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria at 3 psychiatric hospitals in Japan. The diagnoses of the patients were determined based on medical records. As a reference group, 832 healthy volunteers (327 males and 505 females) who participated in the Iwaki Health Promotion Project in 2009 were also included. They were residents of Iwaki district, Hirosaki city, in northern Japan. Iwaki district is a stable community with a population 11, 961. Their demographic data (age and sex) and medical history were obtained from self-report questionnaires and interviews. Data obtained from the meteorological agency website showed that environmental conditions (duration of sunshine, length of day, temperature and humidity) were similar in the three hospitals and control survey . The data collection procedures for this study were approved (no. 2008-122) by the Ethics Committee of the Hirosaki University School of Medicine and all subjects provided written informed consent before participating.
Subject demographic data (age and sex) was obtained from their medical records. Bone mass was evaluated via QUS densitometry using the AOS-100 device (Aloka, Co. Ltd., Tokyo, Japan) at the calcaneus. The AOS-100 evaluates the speed of sound (SOS in m/s) and the transmission index (TI). SOS and TI as measured using the AOS-100, are highly correlated with SOS (r = 0.89) and broadband ultrasound attenuation (BUA) (r = 0.88) measures obtained using a conventional QUS device . The osteosono-assessment index (OSI) was calculated as a function of SOS and TI, using the TI value multiplied by the square of the SOS value . We assessed the precision of quantitative ultrasound densitometry, and intratest precision was calculated from 3 repeated scans with repositioning in 17 volunteers; the short-term coefficient of variation was 2.6% for the OSI measure . Low bone mass was defined as a level equal to or less than -1.0 standard deviation below the mean OSI value of the reference group aged 20 to 39 years old. Severe low bone mass was defined as a level equal to or less than -2.5 standard deviations below the mean OSI value of the reference group.
Subjects were classified into two groups, with recruited schizophrenic patients composing the schizophrenic patient group and community residents composing the general population group. To compare the main demographic and clinical characteristics between schizophrenic patients and the community group, an unpaired Student's t test was performed to analyze continuous variables, and a χ2 test or Fisher's exact test was used for categorical variables. Data are presented as mean ± SD. Subjects were classified into six age groups, with those aged 20 to 69 grouped according to decade and one group for those 70 and older. In addition, subjects were classified into two larger groups (the younger group with those aged 20 to 49, and the older group for those aged 50 and older) to analyze the effect of aging. The relationship between OSI values and age was tested using simple linear regression analysis. To determine the factors associated with the measured OSI value, a general linear model analysis that included age and subject groups was employed. Interactions between age and subject group were also tested in the same model. A value of P < 0.05 was considered significant. The data were analyzed using PASW Statistics software for Windows, V. 18.0.0 (SPSS Inc., Chicago, IL, USA).
Basic characteristics of schizophrenic patients compared to the general community in Japanese subjects
Age subgroup, years
Schizophrenia, mean (SD)
Community, mean (SD)
20 to 29
3.13 ± 0.35
2.97 ± 0.52
30 to 39
2.89 ± 0.49
3.06 ± 0.46
40 to 49
2.76 ± 0.55*
2.96 ± 0.38
50 to 59
2.68 ± 0.43*
2.86 ± 0.32
60 to 69
2.57 ± 0.56*
2.87 ± 0.40
70 or older
2.10 ± 0.37*
2.84 ± 0.51
20 to 29
2.80 ± 0.38
2.88 ± 0.34
30 to 39
2.98 ± 0.67
2.85 ± 0.37
40 to 49
2.72 ± 0.36
2.74 ± 0.32
50 to 59
2.48 ± 0.28
2.55 ± 0.36
60 to 69
2.20 ± 0.30*
2.37 ± 0.24
70 or older
2.08 ± 0.22*
2.27 ± 0.23
Prevalence of low bone mass
Comparison of the prevalence of low bone mass in schizophrenic patients versus the general community in Japanese subjects
Age subgroup, years
Prevalence of low bone mass (t < 1.0)
Prevalence of severe low bone mass (t < 2.5)
20 to 29
30 to 39
40 to 49
50 to 59
60 to 69
70 or older
20 to 29
30 to 39
40 to 49
50 to 59
60 to 69
70 or older
Comparison of OSI with age and disease status in each gender using general linear model
Comparison of osteosono-assessment index (OSI) by age and disease in each gender with general linear model
Group (being schizophrenic)
P < 0.05
P = 0.383
P < 0.001
P < 0.001
Group × age
P < 0.001
P = 0.079
P < 0.001
P < 0.001
This study was designed to evaluate the effects of age and disease on bone mass in patients diagnosed with schizophrenia. In both males and females, schizophrenic patients had lower bone mass than that of the general population in age groups of 60 years and older. A descending trend between mean OSI value and age was observed in both genders in the schizophrenic patients and in the community group. However, a significant interaction between subject group and age in general linear model showed that descending trend of OSI value with aging was accelerated in male schizophrenic patients.
Several previous studies have compared bone mass between schizophrenic patients and the general population. In a large Taiwanese study, Renn et al.  reported that 965 schizophrenic patients had lower bone mass values than those observed in the general population under the age of 50 in both genders. However, bone mass was higher in schizophrenic patients over the age of 60 than in the general population in both genders, indication that an aging effect on bone mass was not observed in schizophrenic patients. However, Kishimoto et al.  reported that bone mass among 74 male schizophrenic patients was lower than in the general population in the age group of 40 to 49 and 55 to 79. Furthermore, Jung et al.  also reported that 229 schizophrenic patients over age 50 had a higher prevalence of osteoporosis than healthy controls. In addition to the comparison studies with the general population, Liu-Seifert et al.  reported that low bone mineral density (BMD) was significantly associated with age in both genders among schizophrenic patients.
One possible explanation for the discrepancies observed regarding aging effects on bone mass among older schizophrenic patients is that those with the greatest bone fracture risk may expire at a relatively young age, leaving a cohort of survivors in the patient group over 60 years of age in the Taiwanese study. Another possible explanation is that the location from which the patients and controls were recruited differed in the Taiwanese study. In the current study, we recruited both patients and controls from the Aomori prefecture to rule out any geography-related effects.
In this study, the trend relating OSI value and aging among schizophrenic patients does not differ from that in the general population in females. One possible explanation is that the effects of menopause on bone loss might exceed those of antipsychotic medication or the disease itself. Estrogen deficiency at menopause leads to increased skeletal remodeling and loss of bone mass . A decrease in estrogen levels can influence the activity of interleukins, which are known to influence dynamic bone homeostasis . The protective effect of estrogen to bone mass might explain the earlier decline of bone mass among male schizophrenic patients than female ones. Another possible explanation is that secretion of estrogen or leptin from stored bodily fat might protect bone loss in female patients with schizophrenia, as these patients have more body fat [24, 25] than the general population. Previous studies [26, 27] have additionally shown a relationship between fat mass and bone mineral density among females.
The mechanism for decreased bone mass among patients with schizophrenia has not been entirely elucidated. However, most antipsychotics block dopamine-D2 receptors, attenuating the inhibitory effect of dopamine on prolactin release from the pituitary gland and resulting in hyperprolactinemia . Previous studies have shown that patients who are treated with antipsychotics have elevated prolactin levels [6, 29], which is correlated with decreased bone mass in schizophrenic patients. Even when a direct effect of prolactin on BMD was not observed, the duration of antipsychotic treatment had a tendency to be associated with decreased BMD , and patients with hyperprolactinemia showed higher rates of bone metabolism, including both bone formation and resorption .
The present study has some limitations. First, measurement of bone mass was based on QUS densitometry instead of DXA scans. There are many researchers who question the precision of peripheral bone mineral density measurements. Previous studies have reported that QUS parameters cannot be used to predict decreased BMD and that the sensitivities and specificities of QUS parameters are not sufficient to allow it to be used as an alternative to DXA [31–33], which is currently the gold standard for measuring BMD [34, 35]. However, most psychiatric clinics do not have access to DXA equipment and DXA scanning is time consuming, costly and exposes patients to radiation, rendering it less than ideal for a large population survey. In contrast, QUS is rapid and portable, making it a suitable method for large studies. For these reasons, we chose to use this method for our study. Second, because all participants of patients and control consisted of volunteers, they may have more interests in their health or be healthier than the outpatient population or general population. Third, not all parameters which could affect bone mass were included in this study such as body mass index, dietary habits, smoking, alcohol intake, physical exercise, duration of illness and treatment, schizophrenic symptoms and medications. Antipsychotic medications in particular may be an important factor, as the use of prolactin-sparing or prolactin-raising antipsychotics might confound the results. Future research should endeavor to consider the effects of drug treatment and lifestyle factors in conjunction with decreased bone mass in schizophrenia.
This study has shown that the patients with schizophrenia have lower bone mass than the general population in older age groups. However, the descending trend between bone mass and aging among male schizophrenic patients is different from that observed in the male community. This suggests that intervention programs to either prevent or delay the onset of osteoporosis among schizophrenic patients might be tailored separately for each gender.
The authors would like to thank all their coworkers for their skillful contributions to the data collection and management in this study. This work was partly supported by a grant from the Hirosaki Research Institute for Neurosciences.
- Howard L, Kirkwood G, Leese M: Risk of hip fracture in patients with a history of schizophrenia. Br J Psychiatry. 2007, 190: 129-134. 10.1192/bjp.bp.106.023671.View ArticlePubMedGoogle Scholar
- Castle D, Wessely S, Der G, Murray RM: The incidence of operationally defined schizophrenia in Camberwell, 1965-84. Br J Psychiatry. 1991, 159: 790-794. 10.1192/bjp.159.6.790.View ArticlePubMedGoogle Scholar
- Delva NJ, Crammer JL, Jarzylo SV, Lawson JS, Owen JA, Sribney M, Weir BJ, Yendt ER: Osteopenia, pathological fractures, and increased urinary calcium excretion in schizophrenic patients with polydipsia. Biol Psychiatry. 1989, 26: 781-793. 10.1016/0006-3223(89)90119-4.View ArticlePubMedGoogle Scholar
- Halbreich U, Rojansky N, Palter S, Hreshchyshyn M, Kreeger J, Bakhai Y, Rosan R: Decreased bone mineral density in medicated psychiatric patients. Psychosom Med. 1995, 57: 485-491.View ArticlePubMedGoogle Scholar
- Abraham G, Halbreich U, Friedman RH, Josiassen RC: Bone mineral density and prolactin associations in patients with chronic schizophrenia. Schizophr Res. 2003, 59: 17-18. 10.1016/S0920-9964(01)00321-8.View ArticlePubMedGoogle Scholar
- Meaney AM, Smith S, Howes OD, O'Brien M, Murray RM, O'Keane V: Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia. Br J Psychiatry. 2004, 184: 503-508. 10.1192/bjp.184.6.503.View ArticlePubMedGoogle Scholar
- de Leon J, Verghese C, Tracy JI, Josiassen RC, Simpson GM: Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol Psychiatry. 1994, 35: 408-419. 10.1016/0006-3223(94)90008-6.View ArticlePubMedGoogle Scholar
- Lindholm J, Steiniche T, Rasmussen E, Thamsborg G, Nielsen IO, Brockstedt-Rasmussen H, Storm T, Hyldstrup L, Schou C: Bone disorder in men with chronic alcoholism: a reversible disease?. J Clin Endocrinol Metab. 1991, 73: 118-124. 10.1210/jcem-73-1-118.View ArticlePubMedGoogle Scholar
- Ataya K, Mercado A, Kartaginer J, Abbasi A, Moghissi KS: Bone density and reproductive hormones in patients with neuroleptic-induced hyperprolactinemia. Fertil Steril. 1988, 50: 876-881.PubMedGoogle Scholar
- Kishimoto T, Watanabe K, Shimada N, Makita K, Yagi G, Kashima H: Antipsychotic-induced hyperprolactinemia inhibits the hypothalamo-pituitary-gonadal axis and reduces bone mineral density in male patients with schizophrenia. J Clin Psychiatry. 2008, 69: 385-391. 10.4088/JCP.v69n0307.View ArticlePubMedGoogle Scholar
- Renn JH, Yang NP, Chueh CM, Lin CY, Lan TH, Chou P: Bone mass in schizophrenia and normal populations across different decades of life. BMC Musculoskelet Disord. 2009, 10: 1-10.1186/1471-2474-10-1.PubMed CentralView ArticlePubMedGoogle Scholar
- Jung DU, Kelly DL, Oh MK, Kong BG, Kang JW, Lee SJ, Shim JC: Bone mineral density and osteoporosis risk in older patients with schizophrenia. J Clin Psychopharmacol. 2011, 31: 406-410. 10.1097/JCP.0b013e318221b123.View ArticlePubMedGoogle Scholar
- Kang C, Speller R: Comparison of ultrasound and dual energy X-ray absorptiometry measurements in the calcaneus. Br J Radiol. 1998, 71: 861-867.View ArticlePubMedGoogle Scholar
- Greenspan SL, Cheng S, Miller PD, Orwoll ES: Clinical performance of a highly portable, scanning calcaneal ultrasonometer. Osteoporos Int. 2001, 12: 391-398. 10.1007/s001980170108.View ArticlePubMedGoogle Scholar
- Meszaros S, Toth E, Ferencz V, Csupor E, Hosszu E, Horvath C: Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. Joint Bone Spine. 2007, 74: 79-84. 10.1016/j.jbspin.2006.04.008.View ArticlePubMedGoogle Scholar
- Rey-Sánchez P, Lavado-García JM, Canal-Macías ML, Gómez-Zubeldia MA, Roncero-Martín R, Pedrera-Zamorano JD: Ultrasound bone mass in schizophrenic patients on antipsychotic therapy. Hum Psychopharmacol. 2009, 24: 49-54. 10.1002/hup.984.View ArticlePubMedGoogle Scholar
- Japan Meteorological Agency: Weather statistics. [http://www.data.jma.go.jp/obd/stats/etrn/index.php]
- Tsuda-Futami E, Hans D, Njeh CF, Fuerst T, Fan B, Li J, He YQ, Genant HK: An evaluation of a new gel-coupled ultrasound device for the quantitative assessment of bone. Br J Radiol. 1999, 72: 691-700.View ArticlePubMedGoogle Scholar
- Nakamura K, Nashimoto M, Tsuchiya Y, Obata A, Miyanishi K, Yamamoto M: Vitamin D insufficiency in Japanese female college students: a preliminary report. Int J Vitam Nutr Res. 2001, 71: 302-305. 10.1024/0300-98220.127.116.112.View ArticlePubMedGoogle Scholar
- Sugawara N, Yasui-Furukori N, Fujii A, Saito M, Sato Y, Nakagami T, Tsuchimine S, Kaneko S: No association between bone mass and prolactin levels among patients with schizophrenia. Hum Psychopharmacol. 2011, 26: 596-601. 10.1002/hup.1250.View ArticlePubMedGoogle Scholar
- Liu-Seifert H, Kinon BJ, Ahl J, Lamberson S: Osteopenia associated with increased prolactin and aging in psychiatric patients treated with prolactin-elevating antipsychotics. Ann N Y Acad Sci. 2004, 1032: 297-298. 10.1196/annals.1314.044.View ArticlePubMedGoogle Scholar
- Lindsay R: The effect of sex steroids on the skeleton in premenopausal women. Am J Obstet Gynecol. 1992, 166: 1993-1996.View ArticlePubMedGoogle Scholar
- Halbreich U, Palter S: Accelerated osteoporosis in psychiatric patients: possible pathophysiological processes. Schizophr Bull. 1996, 22: 447-454.View ArticlePubMedGoogle Scholar
- Nilsson BM, Forslund AH, Olsson RM, Hambraeus L, Wiesel FA: Differences in resting energy expenditure and body composition between patients with schizophrenia and healthy controls. Acta Psychiatr Scand. 2006, 114: 27-35. 10.1111/j.1600-0447.2005.00700.x.View ArticlePubMedGoogle Scholar
- Saarni SE, Saarni SI, Fogelholm M, Heliövaara M, Perälä J, Suvisaari J, Lönnqvist J: Body composition in psychotic disorders: a general population survey. Psychol Med. 2009, 39: 801-810. 10.1017/S0033291708004194.View ArticlePubMedGoogle Scholar
- Baumgartner RN, Stauber PM, Koehler KM, Romero L, Garry PJ: Associations of fat and muscle masses with bone mineral in elderly men and women. Am J Clin Nutr. 1996, 63: 365-372.PubMedGoogle Scholar
- Lim S, Joung H, Shin CS, Lee HK, Kim KS, Shin EK, Kim HY, Lim MK, Cho SI: Body composition changes with age have gender-specific impacts on bone mineral density. Bone. 2004, 35: 792-798. 10.1016/j.bone.2004.05.016.View ArticlePubMedGoogle Scholar
- Haddad PM, Wieck A: Antipsychotic-induced hyperprolactinemia: mechanisms, clinical features and management. Drugs. 2004, 64: 2291-2314. 10.2165/00003495-200464200-00003.View ArticlePubMedGoogle Scholar
- Yasui-Furukori N, Kondo T, Suzuki A, Mihara K, Kaneko S: Comparison of prolactin concentrations between haloperidol and risperidone treatments in the same female patients with schizophrenia. Psychopharmacology. 2002, 162: 63-66. 10.1007/s00213-002-1058-6.View ArticlePubMedGoogle Scholar
- Hummer M, Malik P, Gasser RW, Hofer A, Kemmler G, Moncayo Naveda RC, Rettenbacher MA, Fleischhacker WW: Osteoporosis in patients with schizophrenia. Am J Psychiatry. 2005, 162: 162-167. 10.1176/appi.ajp.162.1.162.View ArticlePubMedGoogle Scholar
- Cetin A, Erturk H, Celiker R, Sivri A, Hascelik Z: The role of quantitative ultrasound in predicting osteoporosis defined by dual X-ray absorptiometry. Rheumatol Int. 2001, 20: 55-59. 10.1007/PL00006857.View ArticlePubMedGoogle Scholar
- Mulleman D, Legroux-Gerot I, Duquesnoy B, Marchandise X, Delcambre B, Cortet B: Quantitative ultrasound of bone in male osteoporosis. Osteoporos Int. 2002, 13: 388-393. 10.1007/s001980200044.View ArticlePubMedGoogle Scholar
- Dane C, Dane B, Cetin A, Erginbas M: The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women. Climacteric. 2008, 11: 296-303. 10.1080/13697130802178471.View ArticlePubMedGoogle Scholar
- Herd RJ, Blake GM, Miller CG, Parker JC, Fogelman I: The ultrasonic assessment of osteopenia as defined by dual X-ray absorptiometry. Br J Radiol. 1994, 67: 631-635. 10.1259/0007-1285-67-799-631.View ArticlePubMedGoogle Scholar
- Frost ML, Blake GM, Fogelman I: A comparison of fracture discrimination using calcaneal quantitative ultrasound and dual X-ray absorptiometry in women with a history of fracture at sites other than the spine and hip. Calcif Tissue Int. 2002, 71: 207-211. 10.1007/s00223-001-2074-y.View ArticlePubMedGoogle Scholar
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