Contet C, Kieffer BL, Befort K. Mu opioid receptor: a gateway to drug addiction. Curr Opin Neurobiol. 2004;14(3):370–8.
Article
PubMed
CAS
Google Scholar
Gorwood P, Le Strat Y, Ramoz N, Dubertret C, Moalic JM, Simonneau M. Genetics of dopamine receptors and drug addiction. Hum Genet. 2012;131(6):803–22.
Article
PubMed
CAS
Google Scholar
Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PRA. The dopamine theory of addiction: 40 years of highs and lows. Nat Rev Neurosci. 2015;16(5):305–12.
Article
PubMed
CAS
Google Scholar
Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F. Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci USA. 2011;108(37):15037–42.
Article
PubMed
PubMed Central
Google Scholar
Vallone D, Picetti R, Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehav Rev. 2000;24(1):125–32.
Article
PubMed
CAS
Google Scholar
Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011;63(1):182–217.
Article
PubMed
CAS
Google Scholar
Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA. Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatr Genet. 2015;25(5):181–93.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA. 2007;104(51):20552–7.
Article
PubMed
PubMed Central
Google Scholar
Clarke T-K, Weiss TN, Weiss T, Ferarro K, Kampman C, Dackis H, et al. The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. Ann Hum Genet. 2014;78(1):33–9.
Article
PubMed
CAS
Google Scholar
Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang B-Z, Krupitsky E, et al. Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet. 2006;15(6):807–19.
Article
PubMed
PubMed Central
CAS
Google Scholar
Manini AF, Jacobs MM, Vlahov D, Hurd YL. Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. J Med Toxicol. 2013;9(2):148–54.
Article
PubMed
PubMed Central
CAS
Google Scholar
Oertel BG, Kettner M, Scholich K, Renne C, Roskam B, Geisslinger G, et al. A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. J Biol Chem. 2009;284(10):6530–5.
Article
PubMed
CAS
Google Scholar
Koller G, Zill P, Rujescu D, Ridinger M, Pogarell O, Fehr C, et al. Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms. Alcohol Clin Exp Res. 2012;36(7):1230–6.
Article
PubMed
CAS
Google Scholar
Levran O, Awolesi O, Linzy S, Adelson M, Kreek MJ. Haplotype block structure of the genomic region of the mu opioid receptor gene. J Hum Genet. 2011;56(2):147–55.
Article
PubMed
CAS
Google Scholar
Arias A, Feinn R, Kranzler HR. Association of an Asn40Asp (A118G) polymorphism in the μ-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend. 2006;83(3):262–8.
Article
PubMed
CAS
Google Scholar
Clarke T-K, Crist RC, Kampman KM, Dackis CA, Pettinati HM, O’Brien CP, et al. Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine. Neurosci Lett. 2013;542:71–5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Dlugos AM, Hamidovic A, Hodgkinson C, Shen PH, Goldman D, Palmer AA, et al. OPRM1 gene variants modulate amphetamine-induced euphoria in humans. Genes Brain Behav. 2011;10(2):199–209.
Article
PubMed
CAS
Google Scholar
Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, et al. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA cooperative study. Alcohol Clin Exp Res. 2007;31(4):555–63.
PubMed
CAS
Google Scholar
Hendershot CS, Claus ED, Ramchandani VA. Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults. Addict Biol. 2016;21:125–35.
Article
PubMed
CAS
Google Scholar
Miranda R, Ray L, Justus A, Meyerson LA, Knopik VS, McGeary J, et al. Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol Clin Exp Res. 2010;34(1):112–22.
Article
PubMed
CAS
Google Scholar
Al-Eitan LN, Jaradat SA, Su SY, Tay GK, Hulse GK. Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent. Pharmacogenomics Pers Med. 2012;5:99–111.
Article
CAS
Google Scholar
Enabah D, El Baz H, Moselhy H. Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder. Am J Drug Alcohol Abuse. 2014;40(4):317–20.
Article
PubMed
Google Scholar
Nikolov MA, Beltcheva O, Galabova A, Ljubenova A, Jankova E, Gergov G, et al. No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case–control sample. Drug Alcohol Depend. 2011;117(1):62–5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rouvinen-Lagerström N, Lahti J, Alho H, Kovanen L, Aalto M, Partonen T, et al. µ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption. Alcohol Alcohol. 2013;48:519–25.
Article
PubMed
PubMed Central
CAS
Google Scholar
Alsafar H, Jama-Alol K, Hassoun AK, Tay G. The prevalence of type 2 diabetes mellitus in the United Arab Emirates: justification for the establishment of the Emirates Family Registry. Int J Diab Dev Ctries. 2012;32(1):25–32.
Article
Google Scholar
Alblooshi H, Hulse GK, El Kashef A, Al Hashmi H, Shawky M, Al Ghaferi H, et al. The pattern of substance use disorder in the United Arab Emirates in 2015: results of a National Rehabilitation Centre cohort study. Subst Abuse Treat Prev Policy. 2016;11(1):19.
Article
PubMed
PubMed Central
Google Scholar
World medical association declaration of helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA. 1997;277(11):925–6.
Article
Google Scholar
Moyer RA, Wang D, Papp AC, Smith RM, Duque L, Mash DC, et al. Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. Neuropsychopharmacology. 2011;36(4):753–62.
Article
PubMed
CAS
Google Scholar
Sasabe T, Furukawa A, Matsusita S, Higuchi S, Ishiura S. Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. Neurosci Lett. 2007;412(2):139–42.
Article
PubMed
CAS
Google Scholar
Al-Eitan LN, Jaradat SA, Hulse GK, Tay GK. Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. BMC Res Notes. 2012;5:497.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gizer IR, Ehlers CL. Genome-wide association studies of substance use: considerations regarding populations and phenotypes. Biol Psychiat. 2015;77(5):423–4.
Article
PubMed
Google Scholar
Iacono WG, Malone SM, McGue M. Behavioral disinhibition and the development of early-onset addiction: common and specific influences. Annu Rev Clin Psychol. 2008;4:325–48.
Article
PubMed
Google Scholar
Malecka I, Jasiewicz A, Suchanecka A, Samochowiec J, Grzywacz A. Association and family studies of DRD2 gene polymorphisms in alcohol dependence syndrome. Postepy higieny i medycyny doswiadczalnej. 2014;68:1257–63.
Article
PubMed
Google Scholar
Francés F, Portolés O, Castelló A, Costa JA, Verdú F. Association between opioid receptor mu 1 (OPRM1) gene polymorphisms and tobacco and alcohol consumption in a Spanish population. Bos J Basic Med Sci. 2015;15(2):31–6.
Google Scholar
Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug Alcohol Depend. 2012;123(1–3):1–6.
Article
PubMed
CAS
Google Scholar
Woodcock EA, Lundahl LH, Burmeister M, Greenwald MK. Functional mu opioid receptor polymorphism [OPRM1 A(118) G] associated with heroin use outcomes in Caucasian males: a pilot study. Am J Addict. 2015;24(4):329–35.
Article
PubMed
PubMed Central
Google Scholar
Ziauddeen H, Nestor LJ, Subramaniam N, Dodds C, Nathan PJ, Miller SR, et al. Opioid antagonists and the A118G polymorphism in the mu-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype. Neuropsychopharmacology. 2016;41:2647–57.
Article
PubMed
PubMed Central
CAS
Google Scholar
Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, et al. Association of the OPRM1 variant rs1799971 (A118G) with non-specific liability to substance dependence in a collaborative de novo meta-analysis of European-ancestry cohorts. Behav Genet. 2016;46(2):151–69.
Article
PubMed
Google Scholar
Lechner WV, Knopik VS, McGeary JE, Spillane NS, Tidey JW, McKee SA, et al. Influence of the A118G polymorphism of the OPRM1 gene and exon 3 VNTR polymorphism of the DRD4 gene on cigarette craving after alcohol administration. Nicotine Tob Res. 2016;18(5):632–6.
Article
PubMed
CAS
Google Scholar
Sullivan D, Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, et al. Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene–gene–environment interaction. Transl Psychiatry. 2013;3:e222.
Article
PubMed
PubMed Central
CAS
Google Scholar