Disability assessment as an outcome measure: a comparative study of Nigerian outpatients with schizophrenia and healthy control
© Akinsulore et al. 2015
Received: 13 April 2015
Accepted: 29 October 2015
Published: 23 November 2015
Background and objective
Schizophrenia is a chronic mental disorder that leads to disability in several aspects of the individual’s personal, social, and occupational functioning. This study assesses and compares the level of disability among Nigerian outpatients with schizophrenia and healthy controls (HC).
A comparative cross-sectional study among 100 schizophrenia outpatients with an ICD-10 diagnosis and 100 HC was conducted over a 4-month period. They completed a questionnaire containing the Zung’s Self-Rating Depression Scale (SDS), the World Health Organization Disability Assessment Schedule-Second Version (WHODAS-II). Symptoms of schizophrenia were assessed with the Positive and Negative Syndrome Scale (PANSS). Student’s t tests and Chi-square were used to compare patient with schizophrenia and healthy control. Pearson correlation and multiple linear regression analyses were used to assess the relationships of socio-demographic and clinical variable with disability.
The patients with schizophrenia reported greater disability than the HC on most of the disability domains of WHODAS-II. They also reported significantly higher mean Zung’s SDS scores than the HC. Depressive symptoms, negative symptoms, and PANSS total were significantly related to all the WHODAS-II domains. The disability summary score was significantly predicted by depressive symptoms, negative and positive symptoms of schizophrenia, number of active symptoms (relapse) of schizophrenia, and marital status [F (5, 94) = 23.90, p < 0.001].
Schizophrenia is a disabling disorder that affects different aspects of a patient’s life. Treatment strategies that target these different aspects may help in reducing disability.
Outcome measurement in psychiatry is a multidimensional construct that involves several independent domains such as clinical symptoms and disability assessment . Disability is an important outcome measure that involves dynamic interactions between an individual’s health conditions and environment (social and attitudinal), quality of life, and the level of stigma experienced by the person [2–4]. Disability is any restriction or the deterioration of the expected functioning of an individual in a particular society by the family or social group or by the affected individual . Therefore, social factors such as gender, unemployment, and family awareness of the nature of illness may influence the evaluation and level of disability in schizophrenia .
Disability in schizophrenia affects several aspects of the individual’s personal, social, and occupational functioning [7, 8]. The affected domains of patient’s daily life include self-care, self-management, vocational and leisure activities, and social relationships . In schizophrenia, disability has been related to four domains of dysfunction which are the positive symptoms, negative symptoms, cognitive impairment, and affective symptoms [9, 10]. Positive symptoms are symptoms such as delusions and hallucinations that are “added on” to a patient’s experience during the course of illness. Also, negative symptoms such as a motivation refer to symptoms that indicate a reduction of normal functioning in the patient.
It is reported that positive symptoms of schizophrenia poorly predict future occupational functioning in schizophrenia [11, 12]. On the other hand, negative symptoms of schizophrenia have been significantly associated with disability in family and social functioning  and have stronger impact on real-world functioning than other symptoms . Disability in schizophrenia has also been reported to be affected by socio-demographic characteristics (such as sex, marital, and employment status), depressive symptoms and cognitive deficit [2, 15, 16]. Reports from developed countries showed that schizophrenia is quite debilitative resulting in personal disabilities that eventually leads to economic loss [2, 15]. In addition, patients with schizophrenia experience greater severity of disability than the healthy controls (HC) [15, 16].
However, there is paucity of scientific data on disabilities among patients with schizophrenia in Nigeria. The majority of studies of disability in mentally ill Nigerians were conducted among elderly patients with disorders other than schizophrenia [17–19]. Gureje and Bamidele  assessed the social, occupational, and residential outcomes of Nigerian patients with schizophrenia and found that substantial proportion of them reported a moderate to severe degree of disability in the area of occupation and social contact. In a recent study, Adegbaju and colleagues  compared disability among adult Nigerian patients with bipolar affective disorder and schizophrenia and found that patients with schizophrenia reported greater disability than bipolar patients. However, they did not evaluate the association between disability and severity of schizophrenia symptoms. Therefore, we undertook this study to assess and compare self-reported disability using the World Health Organization Disability Assessment Schedule-Second Version (WHODAS-II)  in outpatients with schizophrenia and symptoms of schizophrenia. This study also evaluated the impact of disability on the different domains of patient’s life and provided baseline information on disability level among patients with schizophrenia in Nigeria. In this study, we aimed to assess and compare the level of disability among Nigerian outpatients with schizophrenia and healthy control group as well as identify predictors of disability in schizophrenia.
A comparative cross-sectional study conducted in the Mental Health Clinic of the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC) in Ile-Ife, Osun State, South Western Nigeria. The catchment area of OAUTHC includes villages and towns in Osun state and parts of Ekiti, Ondo and Edo states of Nigeria. Enrolment of patients was planned on a 4-month period (January–April 2012), and for each patient, we also enrolled a healthy control (HC) matched for age, gender, and educational level. The patients aged 18–64 years were diagnosed using the International Classification of Diseases tenth edition (ICD-10) , and the Mini International Neuropsychiatric Interview (MINI), English Version 5.0.0 , was also used to confirm the diagnosis. Also, patient must have been followed up for at least 1 year and their last hospital admission must be at least 6 months or above before the date of assessment. Patients with history of significant co-morbid organic disease or mental retardation and significant physical illness such as severe hypertension and diabetes mellitus were excluded from the study. The healthy controls were randomly selected from the residents of Ife Central Local Government Area of Ile-Ife which is divided into eleven wards with several streets. Five wards were randomly selected using simple balloting technique and twenty HC were chosen from each ward. From the list of streets within the selected wards, the first residence was chosen through a random sampling technique and every other third residence was selected subsequently. Only one HC who met the inclusion criteria was selected in each residence until the required number for each ward was achieved. Potential HC were excluded if they ever had a history of psychiatric illness or a family history of psychiatric illness in a first degree relative and significant physical illness. The study was approved by Ethics and Research Committee of OAUTHC. Written informed consent was taken from all the patients and HC after the objectives of the study had been explained to them. The patients and HC completed the socio-demographic questionnaire, the Zung’s SDS, and the WHODAS-II. Patients were also interviewed with MINI and PANSS.
Mini International Neuropsychiatric Interview: The MINI was designed as a brief structured interview for the major axis 1 psychiatric diagnoses in the DSM IV and ICD-10. It has a current (for present symptoms) and a lifetime version (for retrospective diagnosis). The lifetime diagnosis version was used in this study. The instrument has been used in Nigeria [25, 26].
Socio-demographic and clinical characteristics questionnaire: This questionnaire was developed by the authors for this study and was used to collect information from patients as well as their case files. Discrepancies were clarified by detailed questioning of the patients and relatives. The socio-demographic characteristics are age, sex, educational level, marital status, religion, and employment status. The clinical details of patients included age of onset and duration of the illness, number of active symptoms (relapse) of schizophrenia, number of hospitalization due to illness, and dose of current antipsychotic in chlorpromazine equivalents according to standard formulae [27, 28].
Positive and Negative Syndrome Scale (PANSS): The PANSS is a 30-item instrument that gives scores on positive and negative symptoms as well as general psychopathology . For each item, ratings were made on a 1–7 scale of symptom severity. Positive symptoms were assessed with 7 items, while another seven addressed negative symptoms and 16 items assessed general psychopathology symptoms.
Zung’s Self-Rating Depression Scale (SDS): This was developed by Zung  to assess the severity of depressive symptoms. It is a 20-item self-administered questionnaire graded with a 4 point likert scale (Never, occasionally, sometimes, mostly) for each question. The sum of scores (raw scores) for each respondent was converted to a 100 point scale with a score of less than 50 points classified as normal, 50–59 points mild depression, 60–69 points moderate depression, and 70 points and above severe depression.
World Health Organization Disability Assessment Schedule-Second Version: Disability was assessed using the 36-item self-administered version of WHODAS-II . It measures the difficulty the individual has had with performing particular daily activities over a period of 30 days. It consists of 36 likert-formatted questions, divided into six domains: understanding and communicating (D1; six items); getting around (D2; five items); self-care (D3; four items); getting along with others (D4; five items); life activities (D5; eight items); and participation in society (D6; eight items). The final score is calculated using a standardized SPSS algorithm. There are two syntax versions which may be administered according to a respondent’s occupational status: a 36-item version for those currently working and a 32-item version for those not working. The final scores derived from both versions range from 0–100 with higher scores indicating greater severity of disability.
Statistical analyses were performed using the statistical package SPSS version 17.0 (SPSS Inc., Chicago, IL, USA). The Student t test and Chi-square statistics were used to study the differences between the two groups. Correlations between disability and psychiatric symptoms were studied using Pearson’s product moment correlation co-efficient. Multiple linear regression analysis with the stepwise method was used to explore the predictors (socio-demographic and clinical variables) of the disability summary score (DSS) of WHODAS-II. The level of statistical significance was considered to be p < 0.05.
Socio-demographic characteristics of patients with schizophrenia and healthy controls
Schizophrenia (n = 100)
Healthy controls (n = 100)
Test of statistical difference
X 2/t value
Age (years ± SD)
Income per montha
Clinical variables of patients with schizophrenia (n = 100)
Age at onset of illness (years)
Duration of illness (years)
Number of active symptoms (relapse)
Number of hospitalization
Antipsychotic drug use (CPZE in mg)
PANSS general psychopathology
Comparison of patients with schizophrenia and healthy controls
Patients with Schizophrenia (n = 100)
Healthy controls (n = 100)
Disability summary score
Understanding and communicating (D1)
Getting around (D2)
Getting along (D4)
Life activities (5a)
Work activities (5b)a
Participation in society (D6)
Pearson’s correlations of disability scores with psychiatric symptoms
PANSS general psych.
The DSS was significantly predicted by depressive symptoms, negative and positive symptoms of schizophrenia, number of active symptoms (relapse) of schizophrenia, and marital status [F (5, 94) = 23.90, p < 0.001], and this accounted for 56.0 % of the variance (Table 5).
The socio-demographic and clinical variables independently associated with the disability scores by regression analysis
No of active symptoms of schizophrenia (relapse)
Most of the patients were unmarried and this finding is consistent with that of Lane et al.  who reported an over-representation of the unmarried (never married, separated, and divorced) over married in patients with schizophrenia. The higher rate of the unmarried among the patients in this study probably reflects the effects of schizophrenia on interpersonal and intimate relationships . Employment status is an important measure of disability in schizophrenia  and the estimates of unemployment in people with schizophrenia in developed countries have been reported to range between 70 and 85 % . In contrast, the unemployment rate in patients with schizophrenia in Ethiopia (a developing country in Africa) was 45.3 %  which is close to the 37.0 % reported in this study. The differences in the rates of employment can be explained by the fact that jobs are less complicated in the developing countries when compared to jobs in developed countries . Despite the fact that a good percentage of patients were employed, this study has shown that they were poorly remunerated and this makes them to be economically disadvantaged in the community. Therefore, establishing employment programs for patients may help in reducing their level of disability. In this study, the severity of symptoms of schizophrenia was found to be significantly associated with the patients’ levels of disability. There is evidence that negative symptoms are much more related to disability than positive symptoms in schizophrenia [2, 37, 38]. The severity of positive symptoms correlated with the patients’ abilities to understand and communicate, get along, engage in life activities, and participate in the society, whereas the negative symptoms were significantly related to all the domains of WHODAS-II. Therefore, our study also supported that negative symptoms are much more closely related to disability than positive symptoms of schizophrenia. We found that severity of the depressive symptoms was significantly related to all of the WHODAS-II domains and had the strongest association with the disability summary score. This result is consistent with the findings of other studies [16, 39]. Regression analysis predicting the severity of disability indicated that depressive symptoms, negative and positive symptoms of schizophrenia, number of active symptoms (relapse) of schizophrenia, and marital status were significant predictors. Marital status has been shown to be an independent predictor of outcome in studies both in the developed and developing countries [40, 41]. The finding that the number of episodes of active symptoms (relapses) of schizophrenia is predictor of disability indicates the disruptive effect of psychotic symptoms on the patient’s life. Therefore, prevention of relapses will have significant therapeutic and socio-economic implications. This study has some limitations. First, the study was conducted in a single hospital; therefore, the results obtained may not be representative of the schizophrenic patients’ disability scene in Nigeria. Second, the study was cross-sectional: a longitudinal design would have permitted one to learn more about the nature and course, as well as determine the temporal relationship between symptoms of schizophrenia, depression, and level of disability in patients with schizophrenia. Third, we did not validate the self-reported disability with any objective measure and this may have introduced some response biases. Therefore, combination of self-report and objective measure would have been appropriate and truly capture patients level of disability. However, in rehabilitation, assessment of self-reported disability is a valid method as it can be used to explore and understand complex needs of the patients. In addition, WHODAS-II has been shown to be a valid and reliable self-reported instrument for disability assessment that been used extensively in various countries and across different diseases of which mental illness was included . Fourth, some important socio-demographic variables such as family support and type of residence were not studied.
The results of this study have shown that our patients with schizophrenia reported greater disability when compared to healthy control in all the domains of WHODAS-II except in the “getting around” domain. They experience the greatest disability in the “participation in the society” domain of WHODAS-II. Therefore, psychosocial interventions such as social skills training targeted towards increasing patients’ involvement in community activities may help in reducing disability in patients with schizophrenia. The level of disability is associated with the severity of depressive symptoms, negative and positive symptoms of schizophrenia, as well as number of relapse and marital status. This study supported that negative symptoms are much more closely related to disability than positive symptoms of schizophrenia. In summary, future multicenter longitudinal studies with large sample size are needed to determine the directionality of the relationship between disability and symptoms of schizophrenia.
AA conceived the study, reviewed literature and designed the study, contributed to case recruitment, assessment, statistical analyses, interpretation of data, discussion, and drafted the manuscript. BMM participated in case recruitment, assessment, interpretation of data, and discussion. OOA participated in case recruitment, assessment, statistical analyses, interpretation of data, and discussion. IO participated in case recruitment, assessment, interpretation of data, and discussion. FOF contributed to study design, interpretation of data, discussion, and help draft the manuscript. ROAM contributed to study design, interpretation of data, discussion, and help draft the manuscript. All authors read and approved the final manuscript.
We appreciate all the patients with schizophrenia and healthy controls who participated in this study; without their generous support and commitment, our research would not be possible.
The authors declare that they have no competing interests.
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